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Pathogen infection leads to induction of defense responses which includes modulation of gene expression and changes in metabolism plants. Despite of extensive research little is information known about the role of respiration and photosynthesis during pathogen infection in plants. Limited methods are available to measure oxygen dynamics in response to pathogen infection. Here by using an oxygen microsensor we measured oxygen changes in tomato plants infected with avirulent Pseudomonas syringae pv. tomato DC3000. In this method plant is placed in a closed chamber and change in oxygen levels can be measured by an oxygen sensor.
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http://dx.doi.org/10.1007/978-1-4939-7292-0_7 | DOI Listing |
Plant Dis
September 2025
Institute of Plant Protection, University of Belgrade-Faculty of Agriculture, Department of Phytopathology, Nemanjina 6, Belgrade , Serbia, 11080.
The pathogenic soilborne and postharvest fungus , as newly reported pathogen in Serbia, caused significant disease symptoms on carrot roots and seedlings in inoculation assays. In October 2023, machine-washed and cold-stored carrot roots showed symptoms of black rot of patches and abundant sporulation. The influence of the postharvest treatment of machine washing was confirmed by additional sampling at the production site.
View Article and Find Full Text PDFPlant Dis
September 2025
Michigan State University, Department of Plant, Soil and Microbial Sciences, 105 CIPS, East Lansing, Michigan, United States, 48824;
Caliciopsis pinea is the ascomycete plant pathogen that causes caliciopsis canker disease on North American Pinus strobus (eastern white pine). Infections result in downgrading of lumber due to canker formation and overall loss of vigor in P. strobus, which is a critical cover species throughout its native range.
View Article and Find Full Text PDFFundam Clin Pharmacol
October 2025
Postgraduate Program in Pharmaceutical Science, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
This review highlights the integration of drug repurposing and nanotechnology-driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application. The rising prevalence of antifungal resistance and virulence factors of Candida albicans underscore the limitations of current therapies. Statins, commonly used as lipid-lowering agents, have emerged as attractive repurposed drug candidates due to their ability to interfere with fungal ergosterol biosynthesis and Ras-mediated signaling pathways.
View Article and Find Full Text PDFImmunol Res
September 2025
Department of Immunology and Allergy, Faculty of Medicine, Necmettin Erbakan University, Konya, Türkiye.
Background: Variants of uncertain significance (VUS) represent a major diagnostic challenge in the interpretation of genetic testing results, particularly in the context of inborn errors of immunity such as severe combined immunodeficiency (SCID). The inconsistency among computational prediction tools often necessitates expensive and time-consuming wet-lab analyses.
Objective: This study aimed to develop disease-specific, multi-class machine learning models using in silico scores to classify SCID-associated genetic variants and improve the interpretation of VUS.
EMBO J
September 2025
Department of Bacterial Infection and Host Response, Graduate School of Medical and Dental Sciences, Institute of SCIENCE TOKYO, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Many enteric bacterial pathogens deliver virulence effectors to counteract host innate immune responses, such as inflammation and cell death, and colonize the intestinal epithelium. However, host cells recognize the disruption of their innate immune signaling by bacterial effectors and induce alternative immune responses, collectively termed "effector-triggered immunity", to clear bacterial pathogens. Here, we describe a mechanism of cell death induction via effector-triggered immunity and the bacterial countermeasures of the pathogen Shigella flexneri.
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