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Comparison of immune responses to CTLA4 and PD-1 blockade uncovers a role for helper T cells in anti-CTLA-4 therapy.
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http://dx.doi.org/10.1126/sciimmunol.aao6871 | DOI Listing |
Redox Biol
September 2025
College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, 61186, Republic of Korea. Electronic address:
Copper oxide nanoparticles (CuONPs) are increasingly used across various industrial applications, raising concerns about their potential toxicity and necessitating comprehensive safety evaluations. In this study, we first evaluated the respiratory toxicity of CuONP exposure in a mouse model of asthma. CuONP exposure alone exacerbated asthma symptoms, as evidenced by increased airway hyperresponsiveness, inflammatory cell infiltration, and elevated cytokine production with increasing thioredoxin-interacting protein (TXNIP) expression.
View Article and Find Full Text PDFJ Virol
September 2025
Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, USA.
T cells play an important role in initiating antibody responses by instructive signals of cell-cell contacts and secretion of soluble cytokines as mediators. We investigated the role of the modified soluble E2 (sE2) antigen from hepatitis C virus (HCV) on healthy human peripheral blood mononuclear cell (PBMC)-derived immune cells or immunized mouse cells to understand the mechanisms of immune regulation by the candidate vaccine antigen. HCV E2 and E2 displayed a role in inducing type 17 T-helper cell (Th17) phenotype, as indicated by interleukin-17 (IL-17) expression and signal transducer and activator of transcription 3 (Stat3) phosphorylation.
View Article and Find Full Text PDFJ Immunother Cancer
September 2025
Center for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, California, USA
Background: CD4 T cells play a critical role in the positive and negative regulation of cellular immunity through the many functional subsets they comprise. The progressive growth of immunogenic tumors which nonetheless generate mutation-specific T cells suggests that effective immune control may be avoided or suppressed at the level of the neoantigen-specific CD4 T-cell response. Despite their importance, little is known about the ontogeny, architecture, and development of the CD4 NeoAg-specific repertoire induced by progressively growing tumor.
View Article and Find Full Text PDFExp Parasitol
September 2025
Natural Products Drug Discovery Research Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. Electronic address:
Leishmaniasis is a vector-borne parasitic disease caused by Leishmania spp., for which there is no vaccine and an urgent need for better drugs. The zinc metalloprotease gp63 of Leishmania has been identified as an antigenic structure for vaccine design and a promising target for new antileishmanial agents.
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