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Rejection sensitivity is a personality disposition characterized by oversensitivity to social rejection. Using a three-level meta-analytic model, 75 studies were reviewed that examined associations between rejection sensitivity and five mental health outcomes: depression, anxiety, loneliness, borderline personality disorder, and body dysmorphic disorder. The results showed significant and moderate associations between rejection sensitivity and depression (pooled r=0.332; p<0.001), anxiety (pooled r=0.407; p<0.001), loneliness (pooled r=0.386; p<0.001), borderline personality disorder (pooled r=0.413; p<0.001), and body dysmorphic disorder (pooled r=0.428; p<0.001). The associations between rejection sensitivity and depression, anxiety, and borderline personality disorder varied by type of sample, but the associations were similar for clinical and non-clinical (i.e., community) samples. The association between rejection sensitivity and anxiety was negatively moderated by percentage of females in samples. The association between rejection sensitivity and depression was negatively moderated by length of follow-up. The longitudinal associations between rejection sensitivity and depression, anxiety, and loneliness were stable over time. Implications of the findings for both risk assessment and prevention and intervention strategies in mental health practice are discussed.
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http://dx.doi.org/10.1016/j.cpr.2017.08.007 | DOI Listing |
Cardiol Rev
September 2025
Department of Cardiac Surgery, UMC Heart Center, Corporate Fund, Astana, Kazakhstan.
Timely diagnosing and monitoring of primary graft dysfunction is pivotal for heart transplant patient surveillance. Transthoracic echocardiography is the primary noninvasive method for follow-up of heart transplant recipients, which provides comprehensive information on cardiac morphology and function. It is a sensitive tool in diagnosing rejection, helping to improve therapeutic approaches for this condition, and monitoring cardiac function during therapy.
View Article and Find Full Text PDFPsychol Sci
September 2025
School of Educational Psychology and Counselling, Faculty of Education, Monash University.
This study examined the sequence and timing of sexual identity development (SID) milestones among Generation Z LGBTQ+ Australians, focusing on variations across subgroups and their relationship with minority stressors. The study included 490 Australian LGBTQ+ individuals aged 16 to 26, predominantly White ( = 389) and assigned female at birth ( = 402), with a balanced distribution between cisgender and gender-diverse participants. Demographic differences in the timing and achievement of SID milestones were found for sexual and gender identity.
View Article and Find Full Text PDFFront Cell Neurosci
August 2025
Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Objective: To assess the safety and tolerability of intravitreal injection of human retinal progenitor cells (RPCs) at multiple dose levels in adults with non-syndromic retinitis pigmentosa (RP).
Design: A prospective, multicenter, open-label, single-arm, Phase I/IIa safety study of RPCs in adults with RP ( = 28). Two patient cohorts were studied: Cohort 1: BCVA no better than 20/200 and no worse than Hand Motions, and Cohort 2: BCVA no better than 20/40 and no worse than 20/200).
Exp Clin Transplant
August 2025
>From the Department of Gastroenterology, Dokuz Eylul University Hospital, Izmir, Türkiye.
Objectives: Liver transplant has significantly improved the survival of patients with end-stage liver disease, yet long-term transplant recipients often face challenges related to graft function and well-being. We aimed to evaluate the clinical role of vibration-controlled transi-ent elastography for assessment of liver fibrosis and steatosis, with a focus on fibrosis and steatosis, in liver transplant recipients who were over 10 years posttrans-plant. In addition, we aimed to identify factors that influence liver function and quality of life in these patients.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of General Surgery, Faculty of Medicine, Atatürk University, Erzurum, Türkiye.
Rejection following liver and kidney transplantation remains a major barrier to long-term graft survival. Early and reliable detection of rejection is crucial for optimizing patient outcomes and guiding personalized therapeutic approaches. Despite ongoing efforts, currently available serum-based biomarkers often fail to provide sufficient sensitivity and specificity for early diagnosis.
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