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Article Abstract
Mucin is a major component of mucus in gastrointestinal mucosa. Increase of specific sialomucins having Sd blood group antigen, NeuAcα2-3(GalNAcβ1-4)Galβ1-4GlcNAcβ-, is considered to be associated with expulsion of the parasitic intestinal nematode Nippostrongylus brasiliensis. In this study, we examined the relationship between interleukin (IL)-13 pathway and expression of Sd-sialomucins in small intestinal mucosa with N. brasiliensis infection. Nematode infection induced marked increases in small intestinal mucins that reacted with anti-Sd antibody in wild type (wt) mice. However, this increase due to infection was supressed in IL-4 receptor α deficient (IL-4Rα) mice, which lack both IL-4 and IL-13 signaling via IL-4R, and severe combined immunodeficient (SCID) mice, which have defects in B- and T-lymphocytes. Analysis using tandem mass spectroscopy showed that Sd-glycans were not expressed in small intestinal mucins in IL-4Rα and SCID mice after infection despite the appearance of Sd-glycans in the infected wt mice. Inoculation of recombinant IL-13 into the infected SCID mice restored expression of Sd-glycan. Our results suggest that the IL-13/IL-4R axis is important for the production of Sd-sialomucins in the host intestinal mucosa with parasitic nematode infection.
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| http://dx.doi.org/10.1016/j.parint.2017.08.004 | DOI Listing |
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