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Passive ocean observing sensors are unable to detect subsurface structure in ocean properties, resulting in errors in water column integrated phytoplankton biomass and net primary production (NPP) estimates. Active lidar (light detection and ranging) sensors make quantitative measurements of depth-resolved backscatter (bbp) and diffuse light attenuation (Kd) coefficients in the ocean and can provide critical measurements for biogeochemical models. Sub-surface phytoplankton biomass, light, chlorophyll, and NPP fields were characterized using both in situ measurements and coincident airborne high spectral resolution lidar (HSRL-1) measurements collected as part of the SABOR (Ship-Aircraft Bio-Optical Research) field campaign. We found that depth-resolved data are critical for calculating phytoplankton stocks and NPP, with improvements in NPP estimates up to 54%. We observed strong correlations between coincident HSRL-1 and in situ IOP measurements of both bbp (r = 0.94) and Kd (r = 0.90).
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http://dx.doi.org/10.1364/OE.25.013577 | DOI Listing |
Endocr Relat Cancer
September 2025
Endocrinology, Diabetology and Medical Andrology Unit, IRCCS, Humanitas Research Hospital, Rozzano, Milan, Italy.
Bone metastases (BMs) are rare and late event in patients with neuroendocrine tumors (NETs). The aim of our study was to investigate clinical presentation and outcome of BMs in a large cohort of patients with NETs. A retrospective study was performed at two referral centers of Northern Italy (IRCCS Humanitas Research Hospital in Milan and S.
View Article and Find Full Text PDFJ Geriatr Cardiol
August 2025
Interventional Cardiology, Sandro Pertini Hospital, Rome, Italy.
Background: Antithrombotic strategies after percutaneous coronary interventions (PCI) in elderly patients on oral anticoagulant therapy (OAT) are debated due to the balance between ischemic and bleeding risks. Recent guidelines recommend early transitioning from triple antithrombotic therapy to dual antithrombotic therapy, but there are limited data on elderly patients.
Methods: We performed a age-specific analysis of the PERSEO Registry population aimed to compare clinical features, therapeutic strategies, and outcomes of individuals aged ≥ 80 years and < 80 years who were on OAT and underwent PCI with stent.
Front Immunol
September 2025
Department of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Background: Immune checkpoint inhibitors (ICIs) are a cornerstone of systemic therapy for clear cell renal cell carcinoma (ccRCC), yet response rates remain variable and predictive biomarkers are lacking. This study aimed to determine whether baseline levels of myeloid-derived suppressor cells (MDSCs), especially monocytic (M-MDSC) and polymorphonuclear (PMN-MDSC) subtypes, could predict ICI response in ccRCC patients.
Methods: In this prospective cohort study, 20 ccRCC patients receiving ICI-based therapy for at least 3 months were enrolled.
Mach Learn Health
December 2025
Medical Artificial Intelligence and Automation Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.
Online adaptive radiation therapy (ART) personalizes treatment plans by accounting for daily anatomical changes, requiring workflows distinct from conventional radiotherapy. Deep learning-based dose prediction models can enhance treatment planning efficiency by rapidly generating accuracy dose distributions, reducing manual trial-and-error and accelerating the overall workflow; however, most existing approaches overlook critical pre-treatment plan information-specifically, physician-defined clinical objectives tailored to individual patients. To address this limitation, we introduce the multi-headed U-Net (MHU-Net), a novel architecture that explicitly incorporates physician intent from pre-treatment plans to improve dose prediction accuracy in adaptive head and neck cancer treatments.
View Article and Find Full Text PDFFront Health Serv
August 2025
Shangha Municipal Health Commission, Shanghai, China.
Objective: The family doctor system plays a crucial role in promoting the gradient utilization of health resources. However, empirical evidence regarding the use of health services across different levels of care by diabetic patients under family doctor contracts remains limited. This study aimed to investigate the impact of the family doctor system on the gradient utilization of health services among diabetic patients using real-world data.
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