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Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.
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http://dx.doi.org/10.1111/jmp.12298 | DOI Listing |
Cell Rep
September 2025
National Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; State Key Laboratory of Respiratory Health and Multimorbidity, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; Center for
LP-98 is a lipopeptide HIV fusion inhibitor showing strong treatment and pre-exposure prophylaxis efficacies in non-human primates. In this study, we further characterized its pharmacokinetics, long-lasting antiviral activity, and post-exposure prophylaxis (PEP) efficacy using 62 macaques. In cynomolgus macaques, LP-98 achieved high concentrations (C) with a half-life (T) of ∼31 h, and sustained an effective therapeutic concentration for two weeks post-injection.
View Article and Find Full Text PDFMath Biosci Eng
June 2025
Disease Modelling Lab, Department of Mathematics, School of Natural Sciences, Shiv Nadar Institution of Eminence, Gautam Buddh Nagar 201314, India.
In confronting the critical challenge of disease outbreak management, health authorities consistently encourage individuals to voluntarily disclose a potential exposure to infection and adhere to self-quarantine protocols by assuring medical care (hospital beds, oxygen, and constant health monitoring) and helplines for severe patients. These have been observed during pandemics; for example, COVID-19 phases in many middle-income countries, such as India, promoted quarantine and reduced stigma. Here, we present a game-theoretic model to elucidate the behavioural interactions in infection disclosure during an outbreak.
View Article and Find Full Text PDFDuring the cropping seasons of 2019-20, 2020-21, and 2021-22, respectively, lentil genotypes were screened against Stemphylium blight using the Alpha-Lattice Design with three replications at Pulses Research Centre, BARI, Ishurdi, Pabna-6620 under natural and artificial epiphytotic conditions. In case of artificial inoculum condition, the artificial cultured inoculums were sprayed at 1.3 × 10 spores/mL concentration of spores for spore inoculation in the experimental plots.
View Article and Find Full Text PDFJ Exp Med
October 2025
Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Broadly neutralizing antibodies targeting the V2 apex of HIV-1 envelope are desired as vaccine design templates, but few have been described. Here, we report 11 lineages of V2 apex-neutralizing antibodies from simian-human immunodeficiency virus (SHIV)-infected rhesus macaques and determine cryo-EM structures for 9. A single V2 apex-neutralizing lineage accounted for cross-clade breadth in most macaques, and somatic hypermutation relative to breadth was generally low, exemplified by antibody V033-a.
View Article and Find Full Text PDFMicrob Pathog
October 2025
Virology Lab, Department of Life Sciences, School of Natural Sciences, Shiv Nadar Institution of Eminence, Gautam Buddha Nagar, Uttar Pradesh, 201314, India. Electronic address:
Objectives: The rapid evolution of SARS-CoV-2 and the emergence of new variants have resulted in mutations in the Spike protein's receptor-binding domain (RBD), enhancing its binding affinity to the ACE2 receptor and increasing viral transmissibility. This study aims to identify inhibitors that can disrupt the Spike-ACE2 interaction, potentially preventing viral entry and immune evasion. The selected compounds may emerge as putative drugs following further studies.
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