Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Both microenvironment and tumor biomarkers impact outcome in follicular lymphoma (FL). We aimed to study the effect of Ki-67, CD3, CD68, and PD1 expression on outcome of FL.
Materials And Methods: Forty-eight patients were included. Stained slides were visually assessed and marker expression was correlated with outcome. Both intra- and extrafollicular expression of Ki-67, CD68, and PD1 were evaluated. CD3 was evaluated only in the intrafollicular area. The median values of expression served as a cutoff point for low- and high-expression groups.
Results: High extrafollicular PD1 expression predicted superior FFTF (freedom from treatment failure) compared with low expression (5-year 52% vs. 44%, P = .04). Five-year FFTF markedly increased from 37% to 67% (P = .057) in patients with low intrafollicular CD3 expression.
Conclusion: Our study supports the hypothesis that survival in FL depends on the immunologic cross talk between malignant cells and microenvironment; however, the specific types of cells that influence the clinical behavior of FL are still unknown.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clml.2017.06.026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection.
Cell Rep
March 2025
Vaccine Immunology Laboratory, National Institute of Immunology, New Delhi 110067, India. Electronic address:
Dengue-virus-induced humoral immunity can increase the risk of severe disease, but the factors influencing this response are poorly understood. Here, we investigate the contribution of CD4 T cells to B cell responses in human dengue infection. We identify a dominant peripheral PD-1 T cell subset that accumulates in severe patients and could induce B cell differentiation via interleukin-21 (IL-21)-related pathway.
View Article and Find Full Text PDFAnti-PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4+ T cells in germinal centers.
J Clin Invest
April 2024
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Programmed cell death protein 1 (PD-1) is an immune checkpoint marker commonly expressed on memory T cells and enriched in latently HIV-infected CD4+ T cells. We engineered an anti-PD-1 chimeric antigen receptor (CAR) to assess the impact of PD-1 depletion on viral reservoirs and rebound dynamics in SIVmac239-infected rhesus macaques (RMs). Adoptive transfer of anti-PD-1 CAR T cells was done in 2 SIV-naive and 4 SIV-infected RMs on antiretroviral therapy (ART).
View Article and Find Full Text PDFBAFFR expression in circulating T follicular helper (CD4CXCR5PD-1) and T peripheral helper (CD4CXCR5PD-1) cells in systemic lupus erythematosus.
Lupus
August 2023
Grupo de Inmunología Molecular, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
Background: Circulating T follicular helper (cTfh) and T peripheral helper (Tph) subpopulations are shown to be higher in systemic lupus erythematosus (SLE) patients and have been involved in promoting extrafollicular B cell responses. However, a possible association with the B cell activating factor (BAFF), a cytokine mainly related to B cell responses and disease activity in SLE, has not been investigated. Therefore, this study aimed to evaluate the association of cTfh and Tph subpopulations with the BAFF system expression and clinical activity in SLE patients.
View Article and Find Full Text PDFFollicular Lymphoma Microenvironment Traits Associated with Event-Free Survival.
Int J Mol Sci
June 2023
Hematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Article Synopsis
- Follicular Lymphoma (FL) often leads to cycles of remission and relapse, making it nearly incurable, and current prognostic scores don't work well for all patients.
- This study analyzed 49 FL lymph node biopsies to explore the relationship between immune cell types in the tumor microenvironment and patient outcomes, focusing on specific markers like CD56 and CD163.
- Results indicated that certain ratios of immune cells were linked to survival rates, suggesting enhancing macrophage characterization could improve prognosis for FL patients, but further research is needed.
Case Report: Immune Microenvironment and Mutation Features in a Patient With Epstein-Barr Virus Positive Large B-Cell Lymphoma Secondary to Angioimmunoblastic T-Cell Lymphoma.
Front Genet
July 2022
Department of Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
On rare occasions, secondary Epstein-Barr virus (EBV)-associated B-cell lymphoma can develop in patients with angioimmunoblastic T-cell lymphoma (AITL). Here, we describe the tumor microenvironment and mutation features of a patient with EBV + large B-cell lymphoma (LBCL) secondary to AITL. He was admitted to hospital due to a 1-year history of fever and enlarged right inguinal lymph nodes.
View Article and Find Full Text PDF