Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Poor adherence with medicine declines the clinical outcome of pharmacotherapy. It may carry serious sequelae especially in case of antihypertensive drugs like cerebrovascular accident (CVA). This study has been planned to find the association of poor adherence with anti-hypertensive with CVA in diabetic and non- diabetic patients. One hundred CVA patients who were admitted through Emergency in Abbasi Shaheed hospital, a tertiary care hospital in Karachi, were recruited from Jun 2013 till Dec 2013. The criteria of inclusion was, diagnosed case of CVA, with primary hypertension, availability of patient's therapeutic record, consent of the patient or legal successor/heir. The criteria of exclusion was, secondary hypertension, newly diagnosed primary hypertensive patients and complete adherence with medication. Morisky medication adherence scale was applied. Therapeutic record was accessed. The mean age was 62.15 years with 3:1 male to female ratio. Adherence to medicine was graded < 6. Patients with hypertension were 41 and with diabetes and hypertension were 59. Majority of patients were on monotherapy as compared to polytherapy (62% versus 38%).The mode of therapy was significantly different (P<0.05) in the two groups. ACE Inhibitors, Calcium Channel Blockers, Beta Blockers and other agents were used by 45.16%, 35.48%, 16.12% and 03.24% patients respectively. The aforementioned drugs were used by 57.14%, 33.33% and 09.52% respectively in 21 patients who were on anti-hypertensive and oral hypoglycemic agents. A statistical significant difference (P<0.05) was seen in the case of ACE Inhibitors. Similarly they were used by 42.10%, 39.47% and 18.42% in 38 patients respectively, who were on anti-hypertensive and insulin. No statistical significant difference (P>0.05) was seen in any combination (p>0.05). Thus it is concluded that poor adherence with ACE inhibitors may be a risk factor of CVA in diabetic patients using oral hypoglycemic agents.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Socioeconomic inequalities in health behaviours pre- and post-COVID-19 among Japanese school-aged adolescents: a nationally representative three-wave repeated cross-sectional survey.
Environ Health Prev Med
September 2025
Faculty of Medicine, University of the Ryukyus.
Background: Changes in socioeconomic inequalities in health behaviours following the COVID-19 pandemic remain unknown, particularly among Japanese school-aged adolescents. Therefore, in this study, we examined changes in socioeconomic inequalities in school-aged adolescents' health behaviours, including physical activity (PA), screen time (ST), sleep duration, breakfast consumption, and bowel movement frequency, before and after the pandemic.
Methods: This three-wave repeated cross-sectional study utilised data from the 2019, 2021, and 2023 National Sports-Life Survey of Children and Young People in Japan, analysing data from 766, 725, and 604 participants aged 12-18 years, respectively.
Hepatic arterial infusion chemotherapy plus lenvatinib and PD-1 inhibitors versus lenvatinib plus PD-1 inhibitors as first-line treatment for hepatocellular carcinoma with high tumour burden and portal vein tumour thrombus (CHANCE 2416): study protocol of a multicentre, retrospective, target trial emulation design.
BMJ Open
September 2025
Department of Interventional Radiology, The First Hospital of China Medical University, Shenyang, Liaoning, China
Background: Advanced-stage hepatocellular carcinoma (HCC) with high tumour burden and portal vein tumour thrombus (PVTT) is usually associated with poor survival outcomes. Rapid tumour control usually benefits long-term outcomes, which could be hardly achieved by solely systematic targeted and immunotherapy in current guidelines. Hepatic arterial infusion chemotherapy (HAIC) is reported as an effective intervention for rapid decrease of tumour burden.
View Article and Find Full Text PDFWhich factor ımpacts medical traumatic stress for pediatric patients: Scoping review.
J Pediatr Nurs
September 2025
Department of Nursing, Faculty of Health Sciences, Ankara Medipol University, Ankara, Türkiye.
Purpose: The objective of this scoping review was to systematically map, categorize, and synthesize the existing research identifying the factors associated with the development of medical traumatic stress in pediatric patients receiving clinical care.
Methods: This review followed the methodological framework proposed by Booth et al. (2021) and adhered to the PRISMA-ScR guidelines.
Inhaler identification: evaluating a potential screening method for adherence in chronic respiratory disease management.
J Bras Pneumol
September 2025
. Departamento de Pneumologia do Hospital Infante D. Pedro, Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal.
Objectives: This study explores the relationship between inhaler visual identification, naming, and adherence outcomes, and evaluates the potential of combining these factors into a screening tool for identifying poor adherence.
Methods: This observational, prospective study included adult patients with COPD, asthma, or asthma+COPD who had been on chronic inhalation therapy for at least the past year. Data were collected through patient interviews and medical records.
Guideline adherence in surgical decisions for T1 colorectal cancer after endoscopic resection: large language models vs clinicians.
Int J Surg
September 2025
Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Background: Patients with T1 colorectal cancer (CRC) often show poor adherence to guideline-recommended treatment strategies after endoscopic resection. To address this challenge and improve clinical decision-making, this study aims to compare the accuracy of surgical management recommendations between large language models (LLMs) and clinicians.
Methods: This retrospective study enrolled 202 patients with T1 CRC who underwent endoscopic resection at three hospitals.