Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Mechanochemical polymerization of lactide is carried out by using ball milling. Mechanical energy from collisions between the balls and the vessel efficiently promotes an organic-base-mediated metal- and solvent-free solid-state polymerization. Investigation of the parameters of the ball-milling synthesis revealed that the degree of lactide ring-opening polymerization could be modulated by the ball-milling time, vibration frequency, mass of the ball media, and liquid-assisted grinding. Liquid-assisted grinding was found to be an especially important factor for achieving a high degree of mechanochemical polymerization. Although polymer-chain scission from the strong collision energy prevented mechanical-force-driven high-molecular-weight polymer synthesis, the addition of only a small amount of liquid enabled sufficient energy dissipation and poly(lactic acid) was thereby obtained with a molecular weight of over 1×10 g mol .
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cssc.201700873 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pharmaceutical Cocrystals: A Review on Design, Preparation, Application and Challenges.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
September 2025
Department of Pharmaceutics, SMBT College Of Pharmacy, Nashik, Maharashtra, India.
Pharmaceutical cocrystals have emerged as a transformative approach in drug development, enhancing the physicochemical properties of active pharmaceutical ingredients (APIs) such as solubility, bioavailability, stability, and dissolution rate without altering their pharmacological characteristics. Defined as multicomponent crystalline solids composed of two or more neutral molecules in a stoichiometric ratio, cocrystals are formed through non-ionic interactions like hydrogen bonding and π-π stacking. This review explores the evolution, design, preparation, and applications of pharmaceutical cocrystals, highlighting their ability to improve drug performance, enable controlled release, and offer intellectual property opportunities.
View Article and Find Full Text PDFCocrystal Engineering of Low-Melting-Point Pesticides for Replacement of Emulsifiable Concentrates: A Scalable Strategy to Reduce Pesticide-Derived Volatile Organic Compound Emissions.
Environ Sci Technol
September 2025
State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China.
Emulsifiable concentrates (ECs) are a major source of pesticide-derived volatile organic compound (VOC) emissions and environmental toxicity due to their reliance on hazardous organic solvents. Despite global regulatory efforts to promote water-based alternatives, ECs still account for 25% of the market, primarily due to formulation challenges associated with low-melting-point active ingredients. Here, we present a scalable crystal engineering strategy to address this bottleneck.
View Article and Find Full Text PDFMechano-chemical encapsulation of gemcitabine hydrochloride on metal-organic framework, preparation of shaped pellets, delayed drug release, and time-dependent toxicity to PANC-1 cancer cells.
J Drug Deliv Sci Technol
September 2025
Department of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD, 21251, USA.
Gemcitabine is a powerful anticancer antimetabolite drug which is usually administered as hydrochloride salt (GemHCl), but its systemic administration is accompanied by the undesirable "burst" phenomenon and its adverse side effects. To avoid the "burst", drugs can be encapsulated on suitable matrices to yield a local and delayed release. Here, GemHCl was encapsulated on aluminum metal-organic framework MOF-253 by liquid-assisted grinding (LAG) to form a new pharmaceutical composite.
View Article and Find Full Text PDFMechanochemical Solid Form Screening of Zeolitic Imidazolate Frameworks Using Structure-Directing Liquid Additives.
J Am Chem Soc
August 2025
Department of Chemistry, Georgetown University, Washington, D.C 20057, United States.
We demonstrate a systematic application of the mechanochemical liquid-assisted grinding (LAG) methodology to screen for forms of zinc imidazolate (Zn), of fundamental importance as the simplest member of the zeolitic imidazolate framework materials family. The exploration of 45 different liquid additives, selected based on their molecular structure and physicochemical properties has resulted in eight different Zn topological forms, appearing in 13 crystallographically distinct solid forms (including two previously unknown forms of the (BCT) topology), amorphous phases, and the interrupted -ZnH. All prepared topological forms were also explored computationally, using dispersion-corrected periodic density functional theory (DFT) calculations, enabling the rationalization of screening outcomes, and setting the stage for future prediction of additive-directed metal-organic framework (MOF) synthesis.
View Article and Find Full Text PDFDissolution improvement and solubility enhancement of two tumor-associated enzyme inhibitors via the formation of eutectic mixtures.
J Pharm Sci
July 2025
Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Key Laboratory of Marine Biological Resources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, PR China. Electronic address: z
Eutectic mixtures have emerged as an effective means to improve the physicochemical properties of drugs for clinical applications. In this study, two tumor-associated enzyme inhibitors based eutectic mixtures, i.e.
View Article and Find Full Text PDF