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| http://dx.doi.org/10.1016/j.jaci.2017.04.046 | DOI Listing |
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Circulating melanoma cells (CMCs) are responsible for the hematogenous spread of melanoma and, ultimately, metastasis. However, their study has been limited by the low abundance in patient blood and the heterogeneous expression of surface markers. The FDA-approved CellSearch platform enriches CD146-positive CMCs, whose number correlates with progression-free survival and overall survival.
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View Article and Find Full Text PDFCD146 Molecule Expression in B Cells Acute Lymphoblastic Leukemia (B-ALLs): A Flow-Cytometric Marker for an Accurate Diagnostic Workup.
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Hematology, Department of Translational and Precision Medicine, Sapienza University, 00161 Rome, Italy.
Background: B-lineage acute lymphoblastic leukemias (B-ALL) harboring the t(9;22)(q34;q11)/BCR::ABL1 rearrangement represent a category with previously dismal prognosis whose management and outcome dramatically changed thanks to the use of tyrosine kinase inhibitors (TKIs) usage and more recently full chemo-free approaches. The prompt identification of these cases represents an important clinical need.
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Galectin-3 and Soluble CD146 Identify Cardiorenal Injuries in Severe Burn Patients: A Biomarker-Based Approach.
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Department of Anaesthesiology, Critical Care Medicine and Burn Unit, AP-HP, Saint-Louis Hospital, DMU Parabol, FHU PROMICE, Université de Paris, Paris, France.
Article Synopsis
- The study explores the relationship between acute kidney injury (AKI) and myocardial injury (MI) in patients with severe burns, identifying a condition called cardiorenal syndrome (CRS).
- Researchers measured biomarkers galectin-3 (Gal3) and soluble CD146 (sCD146) daily for the first week after admission to evaluate their effectiveness in predicting CRS.
- Results indicated that elevated levels of Gal3 at admission and during the week were significantly associated with CRS, showing good predictive performance, while sCD146 was less reliable in this context.