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The current study examined the processes involved in the preparation of sequencing and timing initiation for multi-component responses. In two experiments, participants performed a reaction time (RT) task involving a three key-press sequence with either a simple (isochronous) or complex (non-isochronous) timing structure. Conditions involved a precue that provided information about all features of the movement (simple RT), no features of the movement (choice RT), sequencing only, or timing structure only. When sequencing was precued, RT decreased significantly as compared to choice RT, indicative of advance preparation of sequencing. When timing was precued, RT decreased significantly compared to choice RT when the timing structure was simple, suggesting that some aspect of timing preparation can occur prior to the go stimulus. However, even when the timing structure was known in advance, RT was still affected by timing complexity, confirming that some aspect of timing preparation cannot occur until after the onset of the stimulus and thus occurs during the RT interval. To explain these findings, we propose a two-component model of preparation for the timing initiation structure in which timing selection occurs in advance but timing implementation must occur following the go signal. These results support and extend previous findings regarding the independence of the processes associated with response sequencing and timing initiation.
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http://dx.doi.org/10.1007/s00426-017-0877-3 | DOI Listing |
Biomed Mater
September 2025
Department of Nanobiotechnology, Faculty of Biological Sciences, , Tarbiat Modares University, Tehran, P.O. Box 14115-154, Iran, Tehran, Tehran Province, 14115-154, Iran (the Islamic Republic of).
It is essential to develop new strategies for wound treatment and skin reconstruction, particularly by scaffolds that replicate the structure and function of native skin. A bilayer scaffold was developed using three-dimensional (3D) bioprinting, based on a uniform chitosan-based formulation for both layers, maintaining material uniformity while offering structural support and promoting cell adhesion. The upper chitosan layer, embedded with NHEK-Neo, is stiffer and mimics the epidermis, while the softer lower layer contains embedded HFFs and HFSCs, mimicking the dermis.
View Article and Find Full Text PDFJ Pediatr Nurs
September 2025
School of Nursing and Midwifery, Griffith University, Queensland, Australia. Electronic address:
Background And Purpose: Siblings of children with chronic health conditions face unique psychosocial challenges, yet their voices remain underrepresented in research. While existing studies primarily rely only on parental proxy reports of sibling well-being or focus on experiences of older siblings or are confined to specific conditions like cancer, there is limited understanding of siblings' experiences more broadly from their voice. This study investigated the experiences of siblings of children with chronic health conditions in Australia from both sibling and parental perspectives.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Maths and Computer Science, Faculty of Science, University of Kinshasa, Kinshasa, The Democratic Republic of the Congo.
Reliable and timely fault diagnosis is critical for the safe and efficient operation of industrial systems. However, conventional diagnostic methods often struggle to handle uncertainties, vague data, and interdependent multi-criteria parameters, which can lead to incomplete or inaccurate results. Existing techniques are limited in their ability to manage hierarchical decision structures and overlapping information under real-world conditions.
View Article and Find Full Text PDFJAAPA
September 2025
Clay W. Walker is an assistant professor of family medicine at Mayo Clinic in Phoenix, AZ; director of didactic education and an assistant professor in the PA program at A.T. Still University in Mesa, AZ; and an adjunct assistant professor at Rush University in Chicago, IL. Thomas Hartman is directo
Hemoptysis, defined as the expectoration of blood originating from the lower respiratory tract, is a clinical symptom with a wide differential diagnosis that ranges from benign to life-threatening causes. Common causes vary by geographic region and care setting, with respiratory infections, malignancy, bronchiectasis, and chronic obstructive pulmonary disease being predominant in resource-rich countries and tuberculosis remaining the leading cause in resource-limited areas. Though most cases are mild and self-limited, hemoptysis can be a life-threatening medical emergency; these cases are associated with a mortality exceeding 50%, primarily due to asphyxia.
View Article and Find Full Text PDFDiabetologia
September 2025
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Aims/hypothesis: Alpha cell dysregulation is an integral part of type 2 diabetes pathophysiology, increasing fasting as well as postprandial glucose concentrations. Alpha cell dysregulation occurs in tandem with the development of insulin resistance and changes in beta cell function. Our aim was to investigate, using mathematical modelling, the role of alpha cell dysregulation in beta cell compensatory insulin secretion and subsequent failure in the progression from normoglycaemia to type 2 diabetes defined by ADA criteria.
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