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Article Abstract
The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; -values for the protein-protein interaction analysis was calculated using permutation. None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362635 | PMC |
| http://dx.doi.org/10.3389/fnmol.2017.00083 | DOI Listing |
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