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http://dx.doi.org/10.1038/cddis.2017.115 | DOI Listing |
Biomed Res Int
August 2025
National Institute for Radiological Protection, China CDC, Beijing, China.
Radiotherapy is commonly used to treat many cancers, and their sensitivity to radiation is crucial for favorable outcomes. This study investigated whether the immediate early response 5 (IER5) protein affects Cdc25B protein expression in HeLa cells after gamma irradiation. IER5 was knocked down using RNA interference (RNAi) in HeLa cells irradiated with 2 or 4 Gy of gamma rays.
View Article and Find Full Text PDFBiomed Pharmacother
August 2025
Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei
Cell division cycle 25 (CDC25) phosphatase is a key cell cycle regulator whose overexpression is linked to tumor malignancy and poor prognosis. Its inhibition suppresses cancer cell growth and induces cell death, making it a promising therapeutic target. In this study, we aimed to develop novel CDC25 inhibitors with therapeutic potential.
View Article and Find Full Text PDFInt J Biochem Cell Biol
September 2025
Department of Respiratory Medicine, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China. Electronic address:
Background: Lung cancer is the primary reason for global cancer-related deaths. Targeted therapy is currently absent for lung squamous cell carcinoma (LUSC), a significant pathological subtype of lung cancer. The gene SPDYE3, a member of the Speedy/Ringo gene family, is highly expressed in different cancer tissues and functions as a cell cycle regulator.
View Article and Find Full Text PDFCell Mol Life Sci
May 2025
Department of Genetics, Liaoning Research Institute of Birth Health and Development, Reproductive Hospital of China Medical University, Shenyang, 110031, China.
Non-obstructive azoospermia (NOA) is among the most severe type of male infertility, which is characterized by the absence of sperm in the ejaculate of affected individuals. The underlying causes of NOA remain largely unidentified, leading to a dearth of effective clinical interventions. This study aimed to explore a potential biomarker for NOA, and to elucidate the underlying mechanisms involved.
View Article and Find Full Text PDFJ Hum Reprod Sci
March 2025
Department of Zoology, Cytogenetics and Genomics Research Unit, University of Calcutta, Taraknath Palit Siksha Prangan, Ballygunge Science College Campus, Kolkata, India.
Background: Idiopathic azoospermia is one of the most common reasons for male infertility, but little is known about its genetic origins. The CDC25A gene, a meiotic core regulator, encodes a phosphatase that triggers the G1/S transition of meiosis. It dephosphorylates and activates CDK2, as well as enhances CDC2-cyclin E, CDK2-cyclin A and CDK1-cyclin B complex formation, which is crucial for chromosome condensation and progression of meiosis.
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