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Background: Intra-operative sensing technology is an alternative to standard techniques in total knee arthroplasty (TKA) for determining balance by providing quantitative analysis of loads and point of contact throughout a range of motion. We used intra-operative sensing (VERASENSE-OrthoSensor, Inc.) to examine pie-crusting release of the medial collateral ligament in knees with varus deformity (study group) in comparison to a control group where balance was obtained using a classic release technique and assessed using laminar spreaders, spacer blocks, manual stress, and a ruler.
Methods: The surgery was performed by a single surgeon utilizing measured resection and posterior-stabilized, cemented implants. Seventy-five study TKAs were matched 1:3 with 225 control TKAs. Outcome variables included the use of a constrained insert, functional- and knee-specific Knee Society score (KSS) at six weeks, four months, and one year post-operatively. Outcomes were analyzed in a multivariate model controlling for age, sex, BMI, and severity of deformity.
Results: The use of a constrained insert was significantly lower in the study group (5.3 vs. 13.8%; p = 0.049). The use of increased constraint was not significant between groups with increasing deformity. There was no difference in functional KSS and knee-specific KSS between groups at any follow-up interval.
Conclusion: An algorithmic pie-crusting technique guided by intra-operative sensing is associated with decreased use of constrained inserts in TKA patients with a pre-operative varus deformity. This may cause a positive shift in value and cost savings.
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http://dx.doi.org/10.1007/s00264-017-3413-6 | DOI Listing |
Indian J Gastroenterol
August 2025
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background: Hyperspectral imaging (HSI), a high-throughput, three-dimensional technology initially developed for remote sensing, has recently garnered increasing interest in applications in gastroenterology and hepatology. We focus on the aspects of HSI clinical research in gastroenterology and hepatology from a more clinically oriented perspective, discussing its prospective trajectories in this field and delving into the current challenges encountered with HSI.
Methods: A comprehensive systematic search was carried out in PubMed, Embase and Web of Science, encompassing studies published up to June 30, 2024.
Lung Cancer
September 2025
Weill Cornell Medical College, New York, NY, USA; Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Background: The identification of high-grade patterns and mucinous features of invasive primary lung adenocarcinoma on biopsy specimens can have implications on therapeutic decisions across all stages of disease. Shape sensing robotic-assisted bronchoscopy (ssRAB) is an emerging modality for the concomitant diagnosis and staging of lung cancer. We evaluated the performance of ssRAB for adenocarcinoma pattern identification, and particularly high-grade patterns, as well as the histopathologic concordance between biopsy and surgical resection specimens.
View Article and Find Full Text PDFIEEE Trans Med Robot Bionics
November 2024
Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37235 USA.
The size limitations and tortuosity of the neurovasculature currently exceed the capabilities of existing robotic systems. Furthermore, safety considerations require a fail-safe design whereby some passive compliance is used for an added layer of safety and for sensing the lateral load on the steerable portion of the catheter. To address these needs, we propose a novel multi-articulated robotic catheter technology that aims to increase technical precision, reduce procedural time and radiation exposure, and enable the semi-automation of catheters during neuroendovascular procedures.
View Article and Find Full Text PDFFront Surg
June 2025
Department of Neurosurgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong SAR, China.
Objectives: To enhance surgical safety with frequent intra-operative neuro-monitoring (IONM) of the blink reflex (BR) in posterior skull base neurosurgery.
Background: There are reports stating the potential of facial nerve function preservation using BR IONM but none stating that it helps to protect corneal sensation and vision.
Methods: A prospective cohort of 42 consecutive patients with lesions in proximity to the brainstem was operated between January 2021 and April 2024.
Front Immunol
May 2025
Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
Introduction: Tumor-residing microbiota poses a new challenge in cancer progression and therapy; however, the functional behavior of patient tumor-derived microbes remains poorly understood. We previously reported the presence of tumor microbiota in intraductal papillary mucinous neoplasms (IPMNs), which are precursors of pancreatic cancer.
Methods: We examined the metabolic and pathogenic potential of clinical microbiota strains obtained from IPMN tumors using various pancreatic cell lines and 3D spheroid models.