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http://dx.doi.org/10.1021/acs.biochem.7b00092 | DOI Listing |
Nucleic Acids Res
September 2025
Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15206, United States.
Tandem repetition is one of the major processes underlying genome evolution and phenotypic diversification. While newly formed tandem repeats are often easy to identify, it is more challenging to detect repeat copies as they diverge over evolutionary timescales. Existing programs for finding tandem repeats return markedly different results, and it is unclear which predictions are more correct and how much room remains for improvement.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
School of Chemical Engineering and Technology, Zhengzhou University, Zhengzhou 450001, China.
d-Amino acid oxidase from (DAAO) is valuable for pharmaceutical and chemical synthesis due to its high enantioselectivity, but its poor thermostability limits extensive application. This study proposed a synergistic strategy of "sequence consensus design coupled with structure modification" to enhance DAAO thermostability. Through homologous sequence analysis and greedy algorithm-based optimization, a triple mutant M3 (S18T/V7I/Y132F) was obtained, showing a 3.
View Article and Find Full Text PDFTop Magn Reson Imaging
October 2025
BIOSPACE LAB, Nesles-la-Vallée, France.
Aims: Cardiac tumors are aggressive and asymptomatic in early stages, causing late diagnosis and locoregional metastasis. Currently, the standard of care uses gadolinium-based contrast agents for MRI, and the associated hypersensitivity reactions are a significant concern, such as gadolinium deposition disease. In addition, the proximity of cardiac lesions closer to vital structures complicates surgical interventions.
View Article and Find Full Text PDFSage Open Pediatr
September 2025
Department of Child Health, Hopexchange medical center, Kumasi, Ghana.
Background: Fever is a common condition in children under 5. Misconceptions surrounding its management can result in poor health outcomes.
Objectives: To assess caregivers' knowledge and home management practices regarding fever in children under 5 in the Northern Region of Ghana.
Nat Genet
September 2025
Institute of Crop Science, NARO, Tsukuba, Japan.