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Purpose: To demonstrate the effectiveness of the endoscopic transcaruncular and transconjunctival approach in the repair of combined medial and inferior orbital wall fractures.
Methods: A retrospective chart review was conducted on 160 patients with combined medial and inferior orbital wall fractures. All patients underwent surgery via an endoscopic transcaruncular and transconjunctival approach without lateral canthotomy, performed by a single surgeon. Porous polyethylene sheets (1.0 mm in thickness) were implanted to cover the orbital defects. The minimal postoperative follow-up period was 6 months. The authors evaluated enophthalmos, diplopia, and ocular motility pre and postoperatively and report surgical complications.
Results: A total of 160 patients were included, comprising 121 men and 39 women. The mean patient age was 33.9 ± 14.1 years, and the mean postoperative follow-up period was 12 months. The average enophthalmos was 3.20 mm preoperatively, and the mean improvement at 6 months after surgery was 2.82 mm. One patient suffered a canalicular laceration after surgery, and another retrobulbar hemorrhage; however, both of these complications resolved with appropriate management. Otherwise, there were no significant surgical complications including newly developed diplopia, decreased visual acuity, or cerebrospinal fluid leakage.
Conclusions: The endoscopic transcaruncular and transconjunctival approach is a useful and promising technique to repair combined medial and inferior orbital wall fractures.
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http://dx.doi.org/10.1097/SCS.0000000000003429 | DOI Listing |
Cleft Palate Craniofac J
September 2025
Otorhinolaryngology-Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
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Department of Human Structure and Repair, Ghent University Faculty of Medicine, Belgium.
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September 2025
School of Pharmacy, Nantong University, Nantong, Jiangsu Province, 226001, China.
In recent years, photosensitizer-based phototherapy has gained increasing attention in antibacterial applications due to its low cost, noninvasive nature, and low drug resistance. Among various materials, porphyrin-based metal-organic frameworks (MOFs) have demonstrated great potential, due to their good biocompatibility, facile designability, and excellent light absorption capabilities that enable highly efficient antibacterial efficacy. However, further optimization of their antibacterial performance remains a key challenge.
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Department of Geriatrics, Tianjin Medical University General Hospital; Tianjin Key Laboratory of Elderly Health; Tianjin Geriatrics Institute, Tianjin, People's Republic of China.
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November 2025
Department of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.
Cell senescence is a state of stable proliferation arrest characterized by morphological changes and high senescence-associated β-galactosidase (SA-β-gal) activity. Inducing senescence in cancer cells is beneficial for cancer therapy due to proliferation arrest, however, the mechanisms underlying this process remain insufficiently understood. Therefore, the present study investigated the mechanisms of radiation-induced cellular senescence in A549 human lung cancer cells, focusing on the DNA damage response and cell cycle regulation.
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