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http://dx.doi.org/10.1016/j.celrep.2017.01.012 | DOI Listing |
Am J Physiol Heart Circ Physiol
September 2025
Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Diminished peak sodium current () is a causative factor for slowed ventricular conduction and cardiac arrhythmias in patients with Duchenne muscular dystrophy (DMD), a devastating muscle disease triggered by dystrophin deficiency. Recently, we showed that chronic administration of the sodium/glucose cotransporter 2 (SGLT2) inhibitor empagliflozin (EMPA) restores diminished peak in ventricular cardiomyocytes from the dystrophin-deficient mouse model of DMD. Here, we aimed to elucidate the underlying mechanism.
View Article and Find Full Text PDFMesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic protein localized in the endoplasmic reticulum (ER) and pivotally involved in maintaining ER homeostasis. MANF plays an important role in mitigating neurodegenerative processes. Aging, the primary risk factor for neurodegenerative diseases (NDDs), is associated with significant alterations in ER function.
View Article and Find Full Text PDFCerebellum
August 2025
Advanced Research Centre, European University of Lefke, Lefke, Mersin, TR-10, Northern Cyprus, Turkey.
Cadmium (Cd) is a widespread environmental pollutant with well-documented neurotoxic effects. The cerebellum, a key region for motor coordination, appears particularly vulnerable to Cd-induced damage. Numerous recent studies have investigated Cd-mediated cerebellar toxicity, yet an integrated interpretation of these findings remains limited.
View Article and Find Full Text PDFCerebellar Purkinje cells (PCs) are among the most vulnerable neurons to alcohol neurotoxicity. Alcohol can induce endoplasmic reticulum (ER) stress and alter the structure and function of PCs. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER stress inducible protein highly expressed in PCs.
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