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Field flow fractionation (FFF) techniques are used to successfully characterize several nanomaterials by sizing nano-entities and producing information about the aggregation/agglomeration state of nanoparticles. By coupling FFF techniques to specific detectors, researchers can determine particle-size distributions (PSDs), expressed as mass-based or number-based PSDs. This review considers FFF applications in the food, biomedical, and environmental sectors, mostly drawn from the past 4 y. It thus underlines the prominent role of asymmetrical flow FFF within the FFF family. By concisely comparing FFF techniques with other techniques suitable for sizing nano-objects, the advantages and the disadvantages of these instruments become clear. A consideration of select recent publications illustrates the state of the art of some lesser-known FFF techniques and innovative instrumental set-ups.
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http://dx.doi.org/10.1007/s00216-017-0180-6 | DOI Listing |
Front Oncol
August 2025
Department of Radiation Oncology, The Affiliated Huizhou Hospital, Guangzhou Medical University, Huizhou, China.
Background: Breast cancer is the foremost malignancy threatening female health. This study aimed to compare the dosimetric performance of Halcyon 3.0 and TrueBeam in Volumetric Modulated Arc Therapy (VMAT) planning for breast cancer.
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December 2025
Division of Plastic Surgery, Department of Surgery, University of Texas Health Science Center, San Antonio, TX, USA.
Introduction: The free fibula flap is a workhorse flap for bony reconstruction of the craniofacial skeleton. The aim of the study was to conduct a systematic review to investigate the postoperative donor site complications and functional outcomes, specifically ankle instability (AI) and gait disturbances (GD), for patients who have received a free fibula flap (FFF) for head and neck cancer reconstruction.
Methods: We designed a PRISMA-compliant systematic review, which was registered prospectively in PROSPERO.
Oral Oncol
August 2025
Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands; Department of Otolaryngology - Head and Neck Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands. Electronic address: R
Purpose: To determine the prognostic value of systemic inflammatory indices and skeletal muscle mass (SMM) as factors for postoperative complications in patients with advanced stages of oral squamous cell carcinoma (OSCC) undergoing free forearm-flap (FFF) reconstruction.
Methods: In this retrospective cohort study of patients who underwent reconstruction of oral cavity defects with FFF after resection of oral cancer the SMM was assessed. Primary predictor variables inflammatory markers neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, lymphocyte-monocyte ratio, systemic immune inflammatory index and systemic inflammatory marker index, and skeletal muscle mass index were determined.
In Vivo
August 2025
Genalyse Genetic Analysis and Reporting Ltd., Istanbul, Türkiye.
Background/aim: This study investigated the acute effects of flattening filter (FF) and flattening filter-free (FFF) beams on gene expression in non-small-cell lung cancer (NSCLC).
Materials And Methods: Thirty-six adult athymic nude mice were divided into five groups. The control group did not undergo any radiotherapy or treatment procedures, whereas in the lung cancer (LCa) group, a cancer model was created but not irradiated.
PLoS One
September 2025
School of Mechanical Engineering, Wollo University, Dessie, Ethiopia.
3D printing has brought significant changes to manufacturing sectors, making it possible to produce intricate, multi-layered designs with greater ease. This study focuses on optimizing the compressive strength (CS) of functionally graded multi-material (PLA/Almond Shell Reinforced PLA) which is fabricated with the aid of the FFF process, a widely used additive manufacturing technique. Six different machine learning models (ML) were utilized to estimate CS using key process parameters, namely print speed (PS), layer height (LH), and printing temperature (PT).
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