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| http://dx.doi.org/10.1016/j.jhep.2017.01.002 | DOI Listing |
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Bayesian estimation of HIV acquisition dates for prevention trials.
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Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, Washington, USA.
Accurate timing estimates of when participants acquire HIV in HIV prevention trials are necessary for determining antibody levels at acquisition. The Antibody-Mediated Prevention (AMP) Studies showed that a passively administered broadly neutralizing antibody can prevent the acquisition of HIV from a neutralization-sensitive virus. We developed a pipeline for estimating the date of detectable HIV acquisition (DDA) in AMP Study participants using diagnostic and viral sequence data.
View Article and Find Full Text PDFChronic hepatitis C mortality in Brazil from 2000 to 2019: An analysis of multiple causes of death.
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Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Introduction: Conventional mortality statistics that concentrate only on the underlying cause of death may offer a limited view of the complexity of this condition and not fully capture the true extent of mortality from hepatitis C.
Objective: To describe and analyze deaths due to chronic hepatitis C (CHC) in Brazil, as both a underlying and multiple cause of death, from 2000 to 2019.
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Effective primer design for genotype and subtype detection of highly divergent viruses in large scale genome datasets.
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Department of Computer Science, Colorado School of Mines, 1501 Illionis St, Golden, 80401, CO, USA.
Identification of microorganisms in a biological sample is a crucial step in diagnostics, pathogen screening, biomedical research, evolutionary studies, agriculture, and biological threat assessment. While progress has been made in studying larger organisms, there is a need for an efficient and scalable method that can handle thousands of whole genomes for organisms with high mutation rates and genetic diversity such as single stranded viruses. In this study, we developed a novel method to identify subsequences for detection of a given species/subspecies in a (meta)genomic sample using the Polymerase Chain Reaction (PCR) method.
View Article and Find Full Text PDFEarly on-treatment LSM reliably predicts liver-related events in CHB patients with significant fibrosis and cirrhosis.
Hepatology
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Liver Research Center, Beijing Friendship Hospital, Capital Medical University, State Key Lab of Digestive Health, National Clinical Research Center of Digestive Diseases, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, Beijing, China.
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Safety, effectiveness, and acceptability of antenatal penicillin allergy evaluation: a systematic review.
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Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount
Objective: Approximately 8-13% of pregnant patients report penicillin allergy. Penicillins and other beta-lactams are widely used in pregnancy but often avoided in these patients, resulting in suboptimal therapy, antimicrobial resistance, higher costs, and increased morbidity for patients and neonates. True penicillin allergy is rare and 95% of unverified penicillin allergies are delabelled on evaluation.
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