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Unlabelled: Physical activity (PA), especially vigorous-intensity PA, has been shown to be related to pain sensitivity. The relationship among PA levels and PA types on endogenous pain inhibition after exercise, termed exercise-induced hypoalgesia (EIH), remains unclear.
Purpose: This studied examined the EIH response to pressure stimuli among college-age women of differing activity levels.
Methods: Fifty women were tested. Pressure pain threshold (PPT) values were assessed before and immediately after isometric handgrip exercise to exhaustion in the right and left forearms. Participant's PA levels were assessed by wearing an accelerometer for seven consecutive days during waking hours, excluding water activities. Participants were classified into four PA groups: met the American College of Sports Medicine aerobic recommendations (AERO), met aerobic and resistance training recommendations (AERO + RT), insufficiently aerobically active but resistance trained (RT), and insufficiently active (IA) based on their measured and self-reported PA level and type.
Results: AERO and AERO + RT had greater vigorous (P < 0.001) and total PA (P < 0.001) compared with RT and IA. EIH was observed for PPT in both right and left arms (P < 0.001), with PPT increasing 7.7% (529 ± 236 vs 569 ± 235 kPa) and 7.0% (529 ± 299 vs 571 ± 250 kPa) in the right and left forearms, respectively. EIH did not differ among activity groups (P = 0.82). PPT values were found to be inversely related to vigorous-intensity PA (r = -0.29).
Conclusions: PA levels and types had no effect on endogenous pain inhibition after exercise in college-age women.
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http://dx.doi.org/10.1249/MSS.0000000000001186 | DOI Listing |
Br J Pain
August 2025
School of Rehabilitation Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Objectives: A significant driver of low back pain (LBP) is adaptations to endogenous pain modulation (EPM). Exercise modulates pain through various mechanisms, however, there is a lack of information on its relation to EPM. The objective of this study was to evaluate the feasibility of a protocol investigating if changes in EPM occurs after exercise therapy.
View Article and Find Full Text PDFElife
August 2025
Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Exercise might lead to a release of endogenous opioids, potentially resulting in pain relief. However, the neurobiological underpinnings of this effect remain unclear. Using a pharmacological within-subject functional magnetic resonance imaging (fMRI) study with the opioid antagonist naloxone and different levels of aerobic exercise and pain, we investigated exercise-induced hypoalgesia ( = 39, 21 female).
View Article and Find Full Text PDFMusculoskelet Sci Pract
October 2025
Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, Spain.
Background: While exercise is a key part of knee osteoarthritis (OA) management, the optimal dose for acute pain relief remains unclear. We aimed to determine the optimal resistance exercise volume to induce exercise-induced hypoalgesia (EIH) in older adults with severe knee OA.
Methods: 28 participants (11/17 women/men; mean age = 71.
J Sci Med Sport
July 2025
École de kinésiologie et des sciences de l'activité physique (EKSAP), Faculté de médecine, Canada; Centre de recherche de l'Institut universitaire de gériatrie de Montréal (CRIUGM), Canada; Centre interdisciplinaire de recherche sur le cerveau et l'apprentissage (CIRCA), Canada.
Objectives: Physical exercise can transiently decrease pain intensity within a single session and improve physical capacities while reducing pain over a training program. However, the pain trajectory throughout a concurrent physical training program remains unknown. This study aimed to model the pain trajectory during a training program including both aerobic and resistance exercises, considering both acute (within-session) and chronic (across-program) effects of physical exercise.
View Article and Find Full Text PDFMol Biol Rep
August 2025
Faculty of Medicine, Department of Physiology, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye.
Chronic low back pain (CLBP) remains a significant challenge for clinicians, and a substantial percentage of adults experience it at some point in their lives. Non-pharmacological treatments have gained attention for managing pain through aerobic and anaerobic core exercises. However, studies on humans and animals have yielded conflicting results regarding the type of exercise and its effect on pain sensation.
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