Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10428194.2016.1233538 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults.
Nat Commun
August 2025
HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
As intrinsic differences in humoral immune response to SARS-CoV-2 between children and adults remain unclear, we improved characterisation by defining the kinetics, specificity and function of antibodies to SARS-CoV-2 in children (n = 146, aged 9.4 ± 4.8 years with n = 257 samples) compared to adults (n = 85, aged 39.
View Article and Find Full Text PDFImmunoPET Demonstrates that Co-Targeting GD2 and B7-H3 with Bispecific Antibodies Enhances Tumor Selectivity in Preclinical Melanoma Models.
Bioconjug Chem
August 2025
Departments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Disialoganglioside 2 (GD2) is overexpressed in multiple cancers, such as melanoma and neuroblastoma, but also in peripheral nerves. To improve current GD2-targeting approaches, next-generation heterodimeric bispecific human IgG antibodies were created, each with one antibody binding fragment (Fab) arm specific for GD2 and the other Fab arm specific for B7-H3 (CD276) to drive tumor selectivity. The avidity and selectivity of our GD2-B7-H3 targeting bispecific antibodies (INV34-6, INV33-2, and INV36-6) were determined by flow cytometry and competition binding assays in GD2/hB7-H3 B78 cells.
View Article and Find Full Text PDFT cells must assess and choose between surveilling large areas, but also engage efficiently with the target cells. This process is translated into variations in speed and turning angle of T cells. In this study, we propose a generalized algorithm to analyze cell migration data with focus on CD8+ T cells, using clustering technique to identify the number of different migration states and Hidden Markov Model to capture the dynamical switching between them.
View Article and Find Full Text PDFValency-affinity mapping of multivalent liposomes for tunable target cell discrimination.
Drug Deliv
December 2025
Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Multivalency can drive high-avidity binding of ligand-functionalized nanoparticles to cells with high target receptor expression, but it can also contribute to off-target binding to low-expression non-target cells. We explored how ligand affinity and liposome valency shape the resulting binding performance index (BPI), defined as the product of the proportion of liposome-bound target cells and that of non-bound non-target cells. Designed ankyrin repeat proteins (DARPins) spanning a wide range of HER2-binding affinities were tethered onto PEGylated liposomes at varying concentrations.
View Article and Find Full Text PDF