Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective:: To investigate the effect of HRE (Hippophae rhamnoides extract) on oral mucositis induced in rats with MTX.
Material And Methods:: Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg HRE while MTXC and HG groups received equivolume distilled water with gavage once a day. After one hour of HRE and distilled water administration, HMTX and MTXC groups received a single dose of oral MTX 5 mg/ kg. This procedure was repeated for one month.
Results:: The levels of MDA, IL-1β, and TNF-α were found to be significantly higher in the cheek, lower lip, and tongue tissue of the animals receiving MTX, compared with HG and HMTX groups; however, these parameters were lower in the cheek and low lip tissue, and a milder damage ocurred in these tissues, compared with the tongue tissue in MTXC group. No histopathologic damage was observed in the cheek, lower lip, and tongue tissues of the rats treated with HRE.
Conclusion:: This findings indicate that HRE as a natural product is an important advantage compared with synthetic drugs for prophylaxis of oral mucositis developed due to MTX.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083018 | PMC |
| http://dx.doi.org/10.1590/1678-775720160139 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Causal relationship between dietary factors and oral mucosal lesions: Two-sample Mendelian randomization analysis.
Medicine (Baltimore)
September 2025
Department of Stomatology, Taikang Tongji (Wuhan) Hospital, Wuhan, Hubei Province, P.R. China.
Previous studies have suggested potential associations between some dietary factors and oral mucosal lesions (OMLs), however, existing research could be biased due to limited sample size and unaccounted confounding factors. This study aimed to explore the causal relationships between 13 common dietary factors and 3 OMLs using 2-sample Mendelian randomization (MR) analysis. Data for the MR analysis were extracted from publicly available genome-wide association study statistics.
View Article and Find Full Text PDFBetrixaban is a broad anti-virus inhibitor by activating innate immunity.
Front Cell Infect Microbiol
September 2025
Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, National Health Commission (NHC) Key Laboratory of Medical Immunology, Peking University Health Science Center, Beijing, China.
The innate immune system serves as the first line of defense against viral infections. Type I interferon (IFN-I) signaling, in particular, plays a crucial role in mediating antiviral immunity. Here, we identify Betrixaban (BT), a novel small-molecule compound that activates innate immune responses, leading to broad-spectrum antiviral effects.
View Article and Find Full Text PDFRole of Local Factors on the Occurrence of Peri-Implantitis: A Cross-Sectional Analysis.
Clin Oral Implants Res
September 2025
School of Dental Medicine, University of Bern, Bern, Switzerland.
Objective: A cross-sectional study was made to evaluate the role of local factors, including surgical, implant, and prosthesis-related parameters, in the presence of peri-implantitis.
Methods: Consecutive partially edentulous patients with ≥ 1 implant presenting peri-implantitis were included. Clinical and radiographic data were collected to characterize local factors.
Cinnamon-Induced Contact Stomatitis: A Retrospective Study of 74 Cases and Literature Review.
Oral Dis
September 2025
Private Practice, Athens, Greece.
Objective: Cinnamon-induced contact stomatitis (CCS) is a hypersensitivity reaction associated with cinnamon-containing products (CCPs). We performed a retrospective study of 74 cases of CCS induced by chewing gums or candies and reviewed the literature.
Materials And Methods: This is a retrospective study of CCS cases, diagnosed during 2010-2025, characterised by temporal association of lesions with the consumption of cinnamon-containing chewing gums or candies; lesion's resolution after discontinuation of those CCPs; and absence of recurrence as long as those CCPs were not re-used.
Predictive models for chemotherapy-induced oral mucositis: a systematic review.
Front Oncol
August 2025
Jianyang Traditional Chinese Medicine Hospital Nursing Department, Chengdu, China.
Objective: To critically appraise and synthesise existing risk prediction models for chemotherapy-induced oral mucositis (CIOM) in cancer patients, identifying their methodological strengths, limitations, and clinical utility to guide future model refinement.
Methods: Relevant literature on CIOM risk prediction models published in PubMed, Cochrane Library, Embase, Web of Science, CNKI, Wanfang Data Knowledge Service Platform, VIP, and CBM was searched, covering the period from the inception of the databases to May 9, 2025. Researchers independently screened the literature and extracted data, utilising the Prediction Model Risk Of Bias Assessment Tool (PROBAST) to evaluate the quality of the models.