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Medication-related osteonecrosis of the jaws (MRONJ) can be considered an inability of the alveolar bone to respond to an injury, which frequently leads to severe local and systemic complications. Once the problem is installed, dentist must use all therapeutic approaches recommended. This manuscript reports a successful management of MRONJ handled with antibiotics, conservative debridement, low-level laser therapy (LLLT), and photodynamic therapy (PDT) up to 12 months. As healing of MRONJ may be very slow, combined therapeutic approaches are required. Besides the recommended conventional treatment protocol, LLLT and PDT are important tools to contribute to healing and improvement of patient's quality of life.
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http://dx.doi.org/10.1155/2016/6267406 | DOI Listing |
Oral Surg Oral Med Oral Pathol Oral Radiol
August 2025
Service d'Odontologie, CHU Clermont-Ferrand, Clermont-Ferrand, France; Université Clermont Auvergne, CHU Clermont-Ferrand, INSERM, Neuro-Dol, Clermont-Ferrand, France. Electronic address:
Medication-related osteonecrosis of the jaw (MRONJ) is a well-documented adverse effect initially linked to antiresorptive agents such as bisphosphonates. Over time, other drug classes have been associated with MRONJ: monoclonal antibodies targeting RANK ligand, monoclonal antibodies targeting VEGF, tyrosine kinase inhibitors, and mammalian target of rapamycin (mTOR) inhibitors. This article presents the case of an 83-year-old female patient referred to the maxillofacial surgery department due to a submental cutaneous fistula with purulent discharge and localized pain.
View Article and Find Full Text PDFJ Oral Maxillofac Surg
August 2025
Professor, Department of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan.
Background: Limited research is available regarding the role of nonoperative therapy in managing medication-related osteonecrosis of the jaw (MRONJ) as it relates to progression or resolution of disease.
Purpose: The study purpose was to estimate the time to MRONJ stage improvement and risk for relapse among patients managed nonoperatively.
Study Design, Setting, Sample: This retrospective cohort study included subjects diagnosed with MRONJ at Keio University Hospital between April 2012 and July 2024.
Cureus
July 2025
Department of Pathology, Matushri Prabhaben Khodabhai Boghara Medical College and Research Centre and Hospital, Atkot, IND.
The increasing prevalence of chronic diseases in the aging global population has led to widespread use of systemic medications, often resulting in polypharmacy among geriatric patients. While these drugs are essential for managing conditions such as hypertension, diabetes, cardiovascular diseases, and autoimmune disorders, their adverse effects on oral health remain underrecognized and insufficiently studied. This review synthesizes current literature alongside cross-sectional observational data to evaluate the multifaceted impact of commonly prescribed systemic medications on oral health outcomes in elderly populations.
View Article and Find Full Text PDFCureus
July 2025
Oral Surgery, Kansai Medical University Medical Center, Moriguchi, JPN.
Diffuse sclerosing osteomyelitis (DSO) is a rare, chronic aseptic osteomyelitis of the mandible characterized by resistance to conventional therapies including nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, corticosteroids, and surgery. Diagnosis is often delayed due to nonspecific symptoms and lack of typical infectious signs, sometimes resulting in misdiagnosis. We report a case of a 58-year-old male patient with persistent mandibular pain initially misdiagnosed as trigeminal neuralgia and treated with microvascular decompression surgery without improvement.
View Article and Find Full Text PDFClin Oral Investig
September 2025
Department of Stomatology, A.C. Camargo Cancer Center, Rua Prof. Antônio Prudente, 211, Liberdade, São Paulo, 01509-900, SP, Brazil.
Objectives: The aim of this study was to evaluate the clinicoradiological features and treatment approaches of MRONJ in cancer patients rehabilitated with osseointegrated implants.
Materials And Methods: Medical records of 147 patients who developed MRONJ over a 16-year period were evaluated. Demographic data, type of antiresorptive medication (AR) used, route of administration, frequency, and time of use were collected.