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Ovarian cystic follicles are the sign of important causes of reproductive failure in numerous species. In this review, some morphological, endocrinological and clinical aspects of cystic follicles in women, cows, mares, sows and bitches are discussed. Follicular cysts are the consequence of the failure of a mature follicle to ovulate at the appointed time of ovulation in the estrous cycle. Although the etiology of follicular cysts remains unknown, this review examines the evidence about the role of endocrine signaling systems in the specific disease or syndrome in each of the species mentioned above. This review also describes, the changes in the pathways of endocrine mechanisms that would trigger disturbances in the intraovarian component underlying the aberrant persistence of follicular cysts. The knowledge of the morphological and endocrinological nature of cystic follicles in different species can provide relevant information to better understand specific diseases when it is integrally analyzed from the comparative medicine viewpoint.
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http://dx.doi.org/10.2174/1381612822666160804100941 | DOI Listing |
J Invest Dermatol
September 2025
Departamento de Biología Molecular, Instituto Universitario de Biología Molecular IUBM-UAM and Centro de Biología Molecular Severo Ochoa (UAM-CSIC), 28049 Madrid, Spain; Instituto de Investigación Sanitaria La Princesa, 28006 Madrid, Spain; CIBER de Enfermedades Cardiovasculares, ISCIII (CIBERCV
Tightly regulated cell-cell and cell-niche intercommunications via intertwined signaling networks are involved in maintaining normal hair follicle (HF) homeostasis, cycling and cell fate determination. However, knowledge of specific mechanisms by which hair loss takes place under pathological situations is needed. Using a keratinocyte-specific knockout mouse model, we uncover that the G-protein-coupled receptor kinase 2 (GRK2) signaling node plays a key role in HF homeostasis.
View Article and Find Full Text PDFAnn Plast Surg
September 2025
Division of Onco-pathology, Department of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Background: Ulceroproliferative lesions involving the eyelids can be due to several causes, chief among them being squamous cell carcinoma (SCC). It is imperative to distinguish it from various mimics owing to the limited surgical therapy that can be offered at the site. Inverted follicular keratosis (IFK) is a rare benign epidermal tumor that arises from the infundibular portion of the hair follicle.
View Article and Find Full Text PDFStem Cell Res Ther
September 2025
State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Polycystic Ovary Syndrome (PCOS), is a complex endocrine disorder affecting 6-21% of reproductive-aged women, characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology. Current clinical management relies on lifestyle modifications and symptom-targeted therapies due to the absence of curative interventions. In recent years, Laparoscopic ovarian drilling (LOD), a surgical procedure that induces controlled ovarian damage to stimulate primordial follicle activation and regulate follicular growth, has emerged as an established therapeutic intervention for infertility in PCOS.
View Article and Find Full Text PDFInt J Surg Pathol
August 2025
Department of Pathology (Histopathology Division), Sir Ganga Ram Hospital, New Delhi, India.
IntroductionTransgender men are assigned female sex at birth, but identify with a masculine gender identity, prompting them to undergo gender-affirming surgery, usually following androgen therapy, which induces changes in histology of hormone sensitive gynecologic organs.MethodsTransgender men undergoing gender-affirming gynecologic surgery, following testosterone therapy (September 2019 to April 2025) were retrospectively included. Histopathology slides were reviewed for features associated with androgen exposure.
View Article and Find Full Text PDFDermatol Ther (Heidelb)
August 2025
Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Acne conglobata is a severe, often eruptive, form of acne included in the follicular occlusion tetrad along with hidradenitis suppurativa, pilonidal cysts, and dissecting cellulitis of the scalp. The pathogenesis is complex and likely multifactorial with contribution from both extrinsic and intrinsic factors. Studies have shown a slight male predominance.
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