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X-ray is still the essential imaging for many minimally-invasive interventions. Overlaying X-ray images with an optical view of the surgery scene has been demonstrated to be an efficient way to reduce radiation exposure and surgery time. However, clinicians are recommended to place the X-ray source under the patient table while the optical view of the real scene must be captured from the top in order to see the patient, surgical tools, and the surgical site. With the help of a RGB-D (red-green-blue-depth) camera, which can measure depth in addition to color, the 3D model of the real scene is registered to the X-ray image. However, fusing two opposing viewpoints and visualizing them in the context of medical applications has never been attempted. In this paper, we propose first experiences of a novel inverse visualization technique for RGB-D augmented C-arms. A user study consisting of 16 participants demonstrated that our method shows a meaningful visualization with potential in providing clinicians multi-modal fused data in real-time during surgery.
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http://dx.doi.org/10.1016/j.compbiomed.2016.08.008 | DOI Listing |
Front Microbiol
August 2025
Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Background: Increasing evidence suggests a potential role of the gut microbiota in Parkinson's disease (PD). However, the relationship between the gut microbiome (GM) and PD dementia (PDD) remains debated, with their causal effects and underlying mechanisms not yet fully understood.
Methods: Utilizing data from large-scale genome-wide association studies (GWASs), this study applied bidirectional and mediating Mendelian randomization (MR) to investigate the causal relationship and underlying mechanisms between the GM and PDD.
Med Phys
September 2025
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China.
Background: In catheter-based radiofrequency ablation (RFA), energy is delivered to heterogeneous thin-walled tissues to induce therapeutic heating. Variations in electrical and mechanical properties of tissue contents have a great effect on outcomes.
Purpose: The objective of this study is to develop models that replicate tissue heterogeneity and visualize ablation zones for effective evaluation and optimization.
ACS Chem Biol
September 2025
Institute for Biomedicine and Glycomics, Griffith University, Queensland, 4111 Brisbane, Australia.
Small-molecule metabolic chemical probes are tailored chemical biology tools that are designed to detect and visualize biological processes within a cell or an organism. Nucleoside analogues are a subset of metabolic probes that enable the study of DNA synthesis, proliferation kinetics, and cell cycle progression. However, most available nucleoside analogue probes have been designed for use in mammalian cells, limiting their use in other species, where there are metabolic pathway differences.
View Article and Find Full Text PDFJ Bone Miner Res
September 2025
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Autosomal Dominant Osteopetrosis (ADO) is a rare, osteosclerotic disorder usually caused by missense variants in the CLCN7 gene, resulting in impaired osteoclastic bone resorption. Penetrance is incomplete and disease severity varies widely, even among relatives within the same family. Although ADO can cause visual loss, osteonecrosis, osteomyelitis, and bone marrow failure, the most common complication of ADO is fracture.
View Article and Find Full Text PDFEye (Lond)
September 2025
Department of Ophthalmology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Background/objectives: Atrial fibrillation (AF) and age-related macular degeneration (AMD) are common debilitating conditions that share pathomechanisms involving chronic inflammation and oxidative stress. However, the association between AMD and AF, which is important for comprehending the pathogenesis, referral, and treatment strategies of these diseases, remains unknown.
Subjects/methods: This nationwide population-based retrospective cohort study used claims data from the National Health Insurance Research Database of Taiwan.