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Background: High-performance throwing athletes may be susceptible to the development of neurogenic thoracic outlet syndrome (NTOS). This condition can be career-threatening but the outcomes of treatment for NTOS in elite athletes have not been well characterized. The purpose of this study was to utilize objective performance metrics to evaluate the impact of surgical treatment for NTOS in Major League Baseball (MLB) pitchers.
Methods: Thirteen established MLB pitchers underwent operations for NTOS between July 2001 and July 2014. For those returning to MLB, traditional and advanced (PitchF/x) MLB performance metrics were acquired from public databases for various time-period scenarios before and after surgery, with comparisons made using paired t-tests, Wilcoxon matched-pair signed-rank tests, and Kruskal-Wallis analysis of variance.
Results: Ten of 13 pitchers (77%) achieved a sustained return to MLB, with a mean age of 30.2 ± 1.4 years at the time of surgery and 10.8 ± 1.5 months of postoperative rehabilitation before the return to MLB. Pre- and postoperative career data revealed no significant differences for 15 traditional pitching metrics, including earned run average (ERA), fielding independent pitching, walks plus hits per inning pitched (WHIP), walks per 9 innings, and strikeouts to walk ratio (SO/BB). There were also no significant differences between the 3 years before and the 3 years after surgical treatment. Using PitchF/x data for 72 advanced metrics and 25 different time-period scenarios, the highest number of significant relationships (n = 18) was observed for the 8 weeks before/12 weeks after scenario. In this analysis, 54 (75%) measures were unchanged (including ERA, WHIP, and SO/BB) and 14 (19%) were significantly improved, while only 4 (6%) were significantly decreased (including hard pitch maximal velocity 93.1 ± 1.0 vs. 92.5 ± 0.9 miles/hr, P = 0.047). Six pitchers remained active in MLB during the study period, while the other 4 had retired due to factors or injuries unrelated to NTOS.
Conclusions: Objective performance metrics demonstrate that pitchers returning to MLB after surgery for NTOS have had capabilities equivalent to or better than before treatment. Thoracic outlet decompression coupled with an ample period of postoperative rehabilitation can provide effective treatment for professional baseball pitchers with career-threatening NTOS.
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http://dx.doi.org/10.1016/j.avsg.2016.05.103 | DOI Listing |
Knee Surg Relat Res
September 2025
Florida Orthopaedic Institute, Gainesville, FL, 32607, USA.
Background: A clear understanding of minimal clinically important difference (MCID) and substantial clinical benefit (SCB) is essential for effectively implementing patient-reported outcome measurements (PROMs) as a performance measure for total knee arthroplasty (TKA). Since not achieving MCID and SCB may reflect suboptimal surgical benefit, the primary aim of this study was to use machine learning to predict patients who may not achieve the threshold-based outcomes (i.e.
View Article and Find Full Text PDFBehav Res Methods
September 2025
Czech Technical University in Prague, Faculty of Electrical Engineering, Department of Cybernetics, Prague, Czech Republic.
Automatic markerless estimation of infant posture and motion from ordinary videos carries great potential for movement studies "in the wild", facilitating understanding of motor development and massively increasing the chances of early diagnosis of disorders. There has been a rapid development of human pose estimation methods in computer vision, thanks to advances in deep learning and machine learning. However, these methods are trained on datasets that feature adults in different contexts.
View Article and Find Full Text PDFOral Radiol
September 2025
Department of Oral and Maxillofacial Radiology, Eskisehir Osmangazi University, Meşelik Campus, Büyükdere Neighborhood, Prof. Dr. Nabi Avcı Boulevard No:4, Odunpazarı, Eskişehir, 26040, Turkey.
Objectives: The primary objective of this study is to evaluate the effectiveness of artificial intelligence-assisted segmentation methods in detecting carotid artery calcification (CAC) in panoramic radiographs and to compare the performance of different YOLO models: YOLOv5x-seg, YOLOv8x-seg, and YOLOv11x-seg. Additionally, the study aims to investigate the association between patient gender and the presence of CAC, as part of a broader epidemiological analysis.
Methods: In this study, 30,883 panoramic radiographs were scanned.
Nat Genet
September 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Aberrant DNA methylation has been described in nearly all human cancers, yet its interplay with genomic alterations during tumor evolution is poorly understood. To explore this, we performed reduced representation bisulfite sequencing on 217 tumor and matched normal regions from 59 patients with non-small cell lung cancer from the TRACERx study to deconvolve tumor methylation. We developed two metrics for integrative evolutionary analysis with DNA and RNA sequencing data.
View Article and Find Full Text PDFSurg Endosc
September 2025
Department of Surgery & Interventional Science, University College London, Gower St, London, WC1E 6BT, UK.
Introduction: The transition from traditional laparoscopy to robotic surgery marks a significant chage in surgical practice. An understated aspect of this transition may be the three dimensional (3D) view from the surgical console. This study hypothesises that acclimatisation with 3D virtual reality (VR) video may enhance robotic simulator performance in novice robotic surgeons.
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