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http://dx.doi.org/10.1111/ijd.13385 | DOI Listing |
Open Access Rheumatol
August 2025
Department of Rheumatology and Immunology, the First Affiliated Hospital, Jinan University, Guangzhou, 510632, People's Republic of China.
Objective: To evaluate the efficacy of baricitinib in combination therapy for managing refractory, rapidly progressive systemic sclerosis (SSc) with severe cardiac conduction defects and interstitial lung disease (ILD).
Methods: A 48-year-old male patient with SSc complicated by significant cardiac enlargement, third-degree atrioventricular block, heart failure, progressive ILD, and partial intestinal obstruction was included in the study. Prior treatments with mycophenolate mofetil (MMF), tacrolimus, and cyclophosphamide (CTX) had shown limited efficacy.
J Control Release
September 2025
Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, Switzerland. Electronic address:
Iron-carbohydrate complexes (ICCs) are widely used nanomedicines to treat iron deficiency anemia, yet their intracellular fate and the mechanisms of action underlying their differences in treatment outcomes remain poorly understood. Here, we thus performed a comprehensive dynamic characterization of two structurally distinct ICCs - iron sucrose (IS) and ferric carboxymaltose (FCM) - in primary human macrophages, key cells to the iron metabolism. By employing innovative correlative microscopy techniques, elemental analysis, and in vitro pharmacokinetic profiling, we demonstrate that the uptake, intracellular trafficking, and biodegradation of ICCs depend on their physicochemical properties.
View Article and Find Full Text PDFCureus
August 2025
Department of Surgery, King Khalid Hospital, Tabuk, SAU.
Background Primary thyroid lymphoma (PTL) is a rare form of thyroid cancer. It is frequently accompanied by Hashimoto's thyroiditis. Treatment approaches differ significantly from those used for other types of thyroid cancer.
View Article and Find Full Text PDFCancer Diagn Progn
September 2025
Institute of Neuropathology, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.
Background/aim: Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by the development of multiple tumors, including plexiform neurofibromas (PNFs), which often affect the craniofacial region and cause significant functional and aesthetic impairments. This report presents long-term surgical management of a patient with hemifacial diffuse PNF, complicated by the emergence of a rapidly enlarging midfacial tumor.
Case Report: The patient was treated for hemifacial invasive diffuse plexiform neurofibroma.
Cureus
July 2025
Family Medicine, Forrest General Hospital, Hattiesburg, USA.
Keratoacanthoma-type crateriform squamous cell carcinoma is an uncommon cutaneous neoplasm that clinically mimics benign keratoacanthoma yet carries malignant potential. This case report describes a 54-year-old Caucasian man with occupational sun exposure and no past medical or significant family history, who developed a rapidly enlarging, dome-shaped nodule with a central keratin plug on his left forearm over six weeks. The lesion was removed via full-thickness fusiform excision with 4 mm margins and closed primarily; histopathology confirmed a crateriform squamous cell carcinoma with clear margins.
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