Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529970 | PMC |
| http://dx.doi.org/10.1136/gutjnl-2016-312398 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Treg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR-Based Genetic Analyses and Experimental Models.
Am J Med Genet B Neuropsychiatr Genet
September 2025
The Central Lab, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD. However, their role in neuroimmune interactions and behavioral outcomes remains poorly understood.
View Article and Find Full Text PDFWhole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
Genome Biol
September 2025
Center for Genomic Medicine, Cardiovascular Research Center, , Massachusetts General Hospital Simches Research Center, 185 Cambridge Street, CPZN 5.238,, Boston, MA, 02114, USA.
Background: Rare genetic variation provided by whole genome sequence datasets has been relatively less explored for its contributions to human traits. Meta-analysis of sequencing data offers advantages by integrating larger sample sizes from diverse cohorts, thereby increasing the likelihood of discovering novel insights into complex traits. Furthermore, emerging methods in genome-wide rare variant association testing further improve power and interpretability.
View Article and Find Full Text PDFCausal Association between Erectile Dysfunction with Urate Levels and Gout: A Two-Sample Mendelian Randomization Study.
Arch Esp Urol
August 2025
Department of Urology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, 214000 Wuxi, Jiangsu, China.
Background: A plethora of studies have demonstrated that the level of uric acid (UA) and gout are the risk factors for erectile dysfunction (ED). However, the causal effect of UA level and gout on ED is still unclear. This Mendelian randomization (MR) study aims to examine the bidirectional causality between ED and UA levels as well as gout.
View Article and Find Full Text PDFExploring multiple myeloma pathobiology and immune cell signatures: Evidence from bidirectional genetic analysis.
Medicine (Baltimore)
September 2025
Department of Geriatrics, Beijing Haidian Hospital, Beijing, China.
The causal relationship between immune cell signatures and multiple myeloma (MM) pathobiology remains incompletely understood. This study aimed to explore the bidirectional causal associations between 731 circulating immune cell traits and MM risk using a two-sample, bidirectional Mendelian randomization (MR) approach. Two-sample MR analyses were conducted utilizing genome-wide association study (GWAS) summary statistics for 731 immune cell phenotypes and MM GWAS datasets.
View Article and Find Full Text PDFGastroesophageal reflux disease and risk of laryngeal cancer: A Mendelian randomization study.
Medicine (Baltimore)
September 2025
Beijing Anzhen Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, Sichuan Province, China.
While observational studies have identified associations between gastroesophageal reflux disease (GERD) and laryngeal cancer (LC), the causal direction remains undetermined. This study employed a bidirectional 2-sample Mendelian randomization (MR) approach complemented by meta-analysis to investigate potential causal relationships between GERD and LC. Analysis leveraged publicly accessible genome-wide association study resources.
View Article and Find Full Text PDF