Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1093/ecco-jcc/jjw140DOI Listing

Publication Analysis

Top Keywords

gut inflammation
4
inflammation mice
4
mice leads
4
leads reduction
4
reduction αvβ8
4
αvβ8 integrin
4
integrin expression
4
expression cd103+cd11b-
4
cd103+cd11b- dendritic
4
dendritic cells
4

Similar Publications

Mouse intestine as a useful model for CFTR electrophysiology function analysis.

Methods Cell Biol

September 2025

Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Italy; CEINGE-Biotecnologie Avanzate, Naples, Italy.

Cystic fibrosis (CF) is a genetic disorder primarily known for its severe impact on lung function, but it also significantly affects the digestive system, leading to complications such as intestinal blockages, malabsorption, inflammation, and microbial dysbiosis. The study of CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) effects on intestinal physiology is critical for developing new effective treatments. This work highlights the use of the mouse intestine as a valuable model for analyzing cellular electrophysiology and CFTR function.

View Article and Find Full Text PDF

Introduction: Combined vascular endothelial growth factor/programmed death-ligand 1 blockade through atezolizumab/bevacizumab (A/B) is the current standard of care in advanced hepatocellular carcinoma (HCC). A/B substantially improved objective response rates compared with tyrosine kinase inhibitor sorafenib; however, a majority of patients will still not respond to A/B. Strong scientific rationale and emerging clinical data suggest that faecal microbiota transfer (FMT) may improve antitumour immune response on PD-(L)1 blockade.

View Article and Find Full Text PDF

Sepsis is a systemic inflammatory response syndrome triggered by infection. Severe sepsis is associated with dysbiosis of the intestinal flora and impaired intestinal function. Ellagic acid (EA) is a natural compound known for its ability to inhibit bacteria and viruses, thereby preventing infections.

View Article and Find Full Text PDF

Microplastic-induced hypertension in rats: A two-hit model exploring oxidative stress and gut microbiota.

NanoImpact

September 2025

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwa

Microplastic particulates (MPs) accumulate widely in ecosystems and pose health risks to both pregnant women and their offspring. Studies have detected MPs in the kidneys and fetal tissues, but it remains unclear whether maternal MP exposure worsens postnatal MP-induced hypertension and kidney disease. This study examined male rat offspring (n = 8/group) divided into four exposure groups: control, indirect (maternal exposure to 1 mg/L MPs during gestation and lactation), direct (offspring exposure to 1 mg/L MPs from 3 to 16 weeks), and combined exposure.

View Article and Find Full Text PDF

Gut microbiome and mitochondrial crosstalk in Schizophrenia, a mental disability: Emerging mechanisms and therapeutic targets.

Neurosci Biobehav Rev

September 2025

Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu District, Tamil Nadu, India. Electronic address:

Gut-mitochondria is an emerging paradigm in understanding the pathophysiology of complex neuropsychiatric disorders such as Schizophrenia (SCZ). This bidirectional communication network connects the gastrointestinal microbiota with mitochondrial function and brain health, offering novel insights into disease onset and progression. SCZ, characterized by hallucinations, delusions, cognitive impairments, and social withdrawal, has traditionally been attributed to genetic and neurochemical imbalances.

View Article and Find Full Text PDF