Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/adma.201602720 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy.
Cell Rep Med
August 2025
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA; Arc Institute, Palo Alto, CA 94304, USA. Electronic address:
Only one in five patients respond to immune checkpoint inhibitors, which primarily target adaptive immunity. Ectonucleotide pyrophosphatase/phophodiesterase 1 (ENPP1), the dominant hydrolase of 2'3'-cyclic-GMP-AMP (cGAMP) that suppresses downstream stimulator of interferon genes (STING) signaling, has emerged as a promising innate immunotherapy target. However, existing ENPP1 inhibitors have been optimized for prolonged systemic residence time rather than effective target inhibition within tumors.
View Article and Find Full Text PDFRegioselective construction of two isomeric BN-fused aromatic frameworks enabling the synthesis of ultralong room-temperature phosphorescence materials.
Chem Sci
August 2025
College of Chemistry and Chemical Engineering, Jiangxi Province Engineering Research Center of Ecological Chemical Industry, Jiujiang University Jiujiang 332005 China
BN-fused aromatic compounds have garnered significant attention due to their unique electronic structures and exceptional photophysical properties, positioning them as highly promising candidates for applications in organic optoelectronics. However, the regioselective synthesis of BN isomers remains a formidable challenge, primarily stemming from the difficulty in precisely controlling reaction sites, limiting structural diversity and property tunability. Herein, we propose a regioselective synthetic strategy that employs 2,1-BN-naphthalene derivatives, wherein selective activation of N-H and C-H bonds is achieved in conjunction with -halogenated phenylboronic acids.
View Article and Find Full Text PDFA bidirectional interfacial engineering strategy for highly stable sodium metal batteries.
Chem Sci
August 2025
Siyuan Laboratory, Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Materials, Guangdong Provincial Key Laboratory of Nanophotonic Manipulation, Department of Physics, College of Physics & Optoelectronic Engineering, Jinan University Guangzhou 510632
Sodium (Na) metal batteries (SMBs) are regarded as some of the most promising next-generation energy storage systems due to their high energy density. However, their practical application is severely hindered by interfacial instabilities at both the anode and cathode, which result in rapid capacity degradation during cycling. Here, we proposed a bidirectional interfacial regulation strategy that simultaneously stabilizes both electrode interfaces.
View Article and Find Full Text PDFGlioblastoma Tumor Microtubes and Brain Fatty Acid-binding Protein: Path to Directional Infiltration.
Neuro Oncol
August 2025
Department of Oncology, Cross Cancer Institute, University of Alberta.
Background: Glioblastoma (GBM) is a deadly brain cancer with a dismal prognosis. There is evidence that infiltration and therapy resistance in GBM are driven by tumor microtubes (TMs), ultra-long membrane-enclosed protrusions that serve as intercellular communication channels. The aims of this study were to investigate the role of TMs and identify the molecular drivers involved in TM formation.
View Article and Find Full Text PDFSecond-Scale Hole Storage in Electrically Driven Multinary Quantum Dots.
Nano Lett
September 2025
Key Lab of Physics and Technology for Advanced Batteries (Ministry of Education), College of Physics, Jilin University, Changchun, 130012, China.
Controlled modulation of charge storage and recombination in light-emitting diodes (LEDs) can function as an artificial memory platform, where charge storage mimics data writing, and recombination corresponds to data readout. Here we demonstrate hole storage lasting up to 0.8 s in an LED using the Cu-In-Zn-S quantum-dot (QD) emissive layer coupled with a deep-energy-level hole transport layer (HTL).
View Article and Find Full Text PDF