Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Houttuynia cordata (HC) (Saururaceae) has been used internally and externally as a traditional medicine and as an herbal tea for healthcare in Japan. Our recent survey showed that HC poultice (HCP) prepared from smothering fresh leaves of HC had been frequently used for the treatment of purulent skin diseases with high effectiveness. Our experimental study also demonstrated that ethanol extract of HCP (eHCP) has antibacterial, antibiofilm, and anti-inflammatory effects against S. aureus which caused purulent skin diseases. In this study, we focused on novel effects of HCP against oral infectious diseases, such as periodontal disease and dental caries. We determined the antimicrobial and antibiofilm effects of water solution of HCP ethanol extract (wHCP) against important oral pathogens and investigated its cytotoxicity and anti-inflammatory effects on human oral epithelial cells. wHCP had moderate antimicrobial effects against some oral microorganisms and profound antibiofilm effects against Fusobacterium nucleatum, Streptococcus mutans, and Candida albicans. In addition, wHCP had no cytotoxic effects and could inhibit interleukin-8 and CCL20 productions by Porphyromonas gingivalis lipopolysaccharide-stimulated human oral keratinocytes. Our findings suggested that wHCP may be clinically useful for preventing oral infectious diseases as a mouthwash for oral care.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931051 | PMC |
| http://dx.doi.org/10.1155/2016/2581876 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Premastication-Review of an Infant Feeding Practice and Its Potential Impact on Allergy and Microbiome Development.
Allergy
September 2025
Department of Paediatrics, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University Frankfurt, Frankfurt am Main, Germany.
Premastication, or pre-chewing, of food as a feeding practice for infants has been practiced across cultures as an ancient evolutionary method. Whilst literature on the topic remains slim, the majority of existing research has highlighted the potential risks, such as transmission of infections. Although the concerns are valid, potential beneficial aspects have, until now, received less attention.
View Article and Find Full Text PDFResearch progress on bioactive peptides in the treatment of oral diseases.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Maxillofacial Surgery, Xiangya Hospital of Stomatology, Central South University, Changsha 410013, China.
Peptide-based drugs possess several advantages, including high specificity, low immunogenicity, minimal accumulation, and fewer drug-drug interactions, making them a novel and efficient therapeutic class for various diseases. In recent years, peptide-based drugs have shown great potential and broad application prospects in the treatment of oral infectious diseases, tissue injury and repair, tumors, and complex oral mucosal disorders, acting either through direct mechanisms or indirect modulation. Oral administration remains the preferred route due to its non-invasive, painless nature and ease of management; however, gastrointestinal pH can inactivate or even degrade peptide drugs.
View Article and Find Full Text PDFReply to the letter regarding the article 'Oral ferric maltol improves iron deficiency anaemia in patients with chronic heart failure'.
Eur J Heart Fail
September 2025
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Evaluation of a nucleic acid preservation protocol for microbiome studies involving samples from the oral cavity.
J Microbiol Methods
September 2025
Dynamics of Respiratory Infections Group, Helmholtz Centre for Infection Research-HZI Braunschweig, Braunschweig, Germany; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, German Center for Lung Research (DZL), BREATH, Hannover, Germany.
Purpose: The accuracy of oral microbiome research depends significantly on specimen sampling protocols, as well as their storage and preservation. Traditional methods, such as freezing, may not only involve logistical hurdles but can also impact the quality of microbial data, leading to difficulties in the comparability between different studies. This study evaluates the effectiveness of the room temperature nucleic acid preservation protocol using DNA/RNA Shield buffer as compared to standard freezing in preserving oral microbial communities over the course of 7 days.
View Article and Find Full Text PDFDevelopment of an in vitro assay using abscisic acid to study Toxoplasma gondii infectivity.
Exp Parasitol
September 2025
Institute of Parasitology, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany; Tifton Veterinary Diagnostic and Investigational Laboratory and Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Tifton, USA. Electronic address: berit.bangoura@u
The common parasite Toxoplasma gondii can infect all warm-blooded animals, including humans. Although most infections in humans remain asymptomatic, clinical toxoplasmosis can develop into a fatal disease. Infections are usually contracted by oral ingestion of tissue cysts or oocysts contained in cat feces.
View Article and Find Full Text PDF