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Synthesis of random copolyester bearing 4-arylidene curcumin M 1 in the polymer backbone was prepared by solution polycondensation method. The influence of copolyester bearing 4-arylidene curcumin M 1 unit on the properties of copolyester such as inherent viscosity, solubility, and thermal stability was investigated and studied in detail. The inherent viscosity and polydispersity index of the copolyester were found to be 0.19 dL/g and 1.38, respectively. The chemical structure of the copolyester was investigated by Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance ((1)H-NMR) spectroscopy. The physical properties of copolyester were characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and X-ray diffraction (XRD) technique. Agar disc diffusion method was employed to study the antimicrobial activity of the random copolyester. In vitro anticancer activity against lung cancer (Hep-2) cell line was investigated.
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http://dx.doi.org/10.1155/2014/495927 | DOI Listing |
J Colloid Interface Sci
May 2025
Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804 China. Electronic address:
Zwitterionic polymers, bearing a pair of oppositely charged groups in their repeat units, have demonstrated significant promise in both biomedical and engineering fields. Tunability of isoelectric points (IEPs) is of great value for bio-applications as it relates to key properties such as the surface charge reversal behavior, biocompatibility and the affinity to biomacromolecules. However, zwitterionic polymers with adjustable IEPs are difficult to obtain due to the fixed combination of ion pairs such as carboxybetaine-, sulfobetaine- and phosphorylcholine-based structures.
View Article and Find Full Text PDFPolymers (Basel)
February 2023
Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorigaoka, Ikeda 563-8577, Osaka, Japan.
We have previously reported that sequence-controlled copolyesters such as poly((ethylene diglycolate) terephthalate) (poly(GEGT)) showed higher melting temperatures than those of the corresponding random copolymers and high biodegradability in seawater. In this study, to elucidate the effect of the diol component on their properties, a series of new sequence-controlled copolyesters composed of glycolic acid, 1,4-butanediol or 1,3-propanediol, and dicarboxylic acid units was studied. 1,4-Butylene diglycolate (GBG) and 1,3-trimethylene diglycolate (GPG) were prepared by the reactions of 1,4-dibromobutane or 1,3-dibromopropane with potassium glycolate, respectively.
View Article and Find Full Text PDFInt J Mol Sci
April 2022
Escuela Nacional de Estudios Superiores, Unidad Morelia, Universidad Nacional Autónoma de México, Antigua Carretera a Pátzcuaro No. 8701, Col. Ex. Hacienda de San José de la Huerta, Morelia C.P. 58190, Michoacán, Mexico.
Unsaturated copolyesters are of great interest in polymer science due to their broad potential applications and sustainability. Copolyesters were synthesized from the ring-opening metathesis copolymerization of -6-hexadecenlactone (HDL) and norbornene (NB) using ruthenium-alkylidene [Ru(Cl)(=CHPh)(1,3-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)(PCy)] (), [Ru(Cl)(=CHPh)(PCy)] (), and ruthenium-vinylidene [RuCl(=C=CH(-CHCF))(PCy)] () catalysts, respectively, yielding HDL-NB copolymers with different ratios of the monomer HDL in the feed. The activity of -heterocyclic-carbene (NHC) () and phosphine ( and ) ligands containing ruthenium-carbene catalysts were evaluated in the synthesis of copolymer HDL-NB.
View Article and Find Full Text PDFChemosphere
June 2021
College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, No.29, 13th Avenue, TEDA, 300457, Tianjin, PR China. Electronic address:
A series of biodegradable copolyester of poly (butylene succinate-co-butylene malate) (P (BS-co-BM)) bearing hydroxyl groups were prepared by one-pot synthetic strategy without hydroxy-protection. The structure and properties of the P (BS-co-BM) were characterized by nuclear magnetic resonance (H NMR), thermogravimetry analysis (TGA), differential scanning calorimetry (DSC), polarized optical microscope (POM), contact angle tester and enzymatic degradation. The results showed that the P (BS-co-BM) manifested excellent thermal properties.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
October 2020
Department of Biomedical Engineering, Integrated Science and Technology Center, Yale University, 600 West Campus Drive, West Haven, CT 06516, United States. Electronic address:
PEGylated lactide-diester-diol copolymers were successfully synthesized via lipase-catalyzed copolymerization, the resultant amphiphilic PEG-poly(L-lactate-co-hexamethylene-co-adipate) (PEG-PLLHA) and PEG-poly(D,L-lactate-co-hexamethylene-co-adipate) (PEG-PDLLHA) block copolymers readily undergo self-assembly processes to form nanosized micelles in aqueous medium, which are stable under physiological conditions in the presence of serum proteins. By conjugating folic acid (FA) to enzymatic synthesized poly(hexamethylene adipate-co-hexamethylene 2,3-epoxy succinate), we could formulate FA-bearing PEG-polyester micelles for docetaxel (DTX) targeting delivery. FA-PEG-PLLHA and FA-PEG-PDLLHA micelles possess efficient cell-targeting capability toward FA receptor-positive cancer cells (e.
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