Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aim: Joint biomarker panel takes advantage of coherence across multiple level datasets and holds the promise to improve disease diagnosis accuracy.
Methods: We collected 101 colorectal cancer and 95 benign samples, measured the molecular concentrations by serum assays and mass spectra, and developed LPGLO (Linear Programming based on Group Lasso Optimization) to identify the joint biomarker panel.
Results: A joint biomarker panel, with ten serum biomarkers and six mass spectra peaks, achieves LOOCV accuracy 0.8724, which is better than the optimal panels identified from separate datasets (LOOCV = 0.7551 for mass spectra only or 0.8265 for serum assay only) and the simply merged dataset (LOOCV = 0.8622).
Conclusion: LPGLO is useful to identify joint biomarker panel to help tumor diagnosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/bmm-2015-0022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Global challenges in diabetes research and care: which way forward? An appraisal from the EASD Global Council.
Diabetologia
September 2025
Department of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
This review article, developed by the EASD Global Council, addresses the growing global challenges in diabetes research and care, highlighting the rising prevalence of diabetes, the increasing complexity of its management and the need for a coordinated international response. With regard to research, disparities in funding and infrastructure between high-income countries and low- and middle-income countries (LMICs) are discussed. The under-representation of LMIC populations in clinical trials, challenges in conducting large-scale research projects, and the ethical and legal complexities of artificial intelligence integration are also considered as specific issues.
View Article and Find Full Text PDFPlasma Proteomic High-Performance Biomarkers for Early Diagnosis of Colorectal Cancer.
J Proteome Res
September 2025
Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Colorectal cancer (CRC) is a major global health challenge due to its high incidence, mortality, and low rate of early detection. Early diagnosis, targeting precancerous lesions (advanced adenomas) and early stage CRC (Tis and T1), is critical for improving patient survival. Given the limitations of current detection methods for advanced adenomas, developing high-performance early diagnostic strategies is essential for effective prevention.
View Article and Find Full Text PDFEffects of different negative pressure cupping interventions on inflammatory response and motor function recovery in delayed onset muscle soreness.
Front Sports Act Living
August 2025
School of Physical Education, Zhejiang Guangsha Vocational and Technical University of Construction, Dongyang, China.
Introduction: This study examined the impacts of different negative pressure cupping therapies (PCT) on pain relief, functional recovery, and inflammatory regulation in delayed onset muscle soreness (DOMS) after high-intensity exercise, with the aim of clarifying the dose-effect relationship.
Methods: In this study, 55 healthy male participants aged 18-25 were selected and divided into 5 groups: the control group (CTR; = 11) and NPCT groups at different levels (-25 kPa, -35 kPa, -45 kPa, and -55 kPa; = 11 in each group). A high-intensity protocol, which included 6 sets of lunges, squats, and squat jumps, was adopted to induce DOMS in the quadriceps femoris.
Integrated Single-Cell and Transcriptome Analysis with Experimental Validation Reveals PANoptosis-Related Gene Signatures in the Immune Microenvironment of Autoimmune Thyroiditis.
J Inflamm Res
September 2025
The Second Clinical College of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People's Republic of China.
Purpose: Autoimmune thyroiditis (AIT) is the most common organ-specific autoimmune disease, and its pathogenesis is closely related to the inflammatory microenvironment driven by immune cell penetration. The role of the newly proposed concept of PANoptosis in immune-related diseases is gradually being revealed. However, there is currently a lack of reports on PANoptosis in AIT.
View Article and Find Full Text PDFCircadian rhythms are associated with higher amyloid-β and tau and poorer cognition in older adults.
Brain Commun
September 2025
Alzheimer's Disease Cooperative Study (ADCS), Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Several studies implicate circadian rhythm disturbances in Alzheimer's disease. However, very little is known about how circadian rhythms are associated with Alzheimer's pathological biomarkers in older adults at early stages of the disease, and how these relationships map onto cognition. This cross-sectional study used 24-h accelerometry data to investigate the relationships between circadian rhythms, amyloid-β (Aβ), tau, and cognition in 68 older adults with objective early cognitive impairment.
View Article and Find Full Text PDF