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http://dx.doi.org/10.1093/jac/dkw138 | DOI Listing |
Vet Sci
August 2025
Institute of Oncology "Prof. Dr. Alexandru Trestioreanu", 252 Fundeni Road, District 2, 022328 Bucharest, Romania.
Toxic shock syndrome (TSS) is a serious, often fatal disease, rarely occurring in dogs via infection with and . The development of TSS is mainly dependent on the presence of bacterial toxins recognized to be potent superantigens causing the release of massive amounts of host inflammatory cytokines, notably TNF-α, progressing to high fever, hypotension, haemoconcentration, thrombosis and neutrophil and endothelial activation with multiple organ failure. Rarely, TSS is associated with erythematous and exfoliative dermatitis progressing to ulceration with extremely extensive dermo-epidermal detachment, which is often very painful.
View Article and Find Full Text PDFAntibiotics (Basel)
June 2025
Veterinary Bacteriology Service, Sciensano, 1050 Brussels, Belgium.
: Methicillin-resistant (MRSA) and methicillin-resistant (MRSP) represent important antimicrobial resistance threats related to companion animals, which can directly or indirectly lead to adverse health effects in humans and animals living in close contact. Characterizing the phenotypic resistance of MRSA and MRSP to a panel of antimicrobials relevant to both veterinary and human medicine is crucial within a "One Health" framework. : In this study, a total of 79 presumptive MRSA isolates (34 from cats, 45 from dogs) and 110 presumptive MRSP isolates (105 from dogs, 5 from cats) from clinical cases were analysed.
View Article and Find Full Text PDFJ Immunother Cancer
July 2025
University of Washington, Seattle, Washington, USA
Background: Napsin A is normally expressed in human lung pneumocytes and is a highly expressed cancer antigen in lung adenocarcinoma. We examined whether T cells specific for Napsin A may play a role in immune checkpoint inhibitor (ICI)-mediated responses. We used bulk T-cell receptor (TCR) repertoire data to assess whether the presence of Napsin A-specific clonotypes in the peripheral blood was associated with improved clinical responses to ICI.
View Article and Find Full Text PDFBMC Infect Dis
July 2025
Department of Medical Microbiology, University of Ghana Medical School, Korle Bu, P.O. Box KB 4236, Accra, Ghana.
Coagulase-negative staphylococci (CoNS) represent a diverse group of opportunistic pathogens associated with human and animal infections. The burden of infectious diseases attributed to antibiotic-resistant CoNS, particularly methicillin-resistant CoNS (MR-CoNS), is a global public health concern. However, there is limited data on the epidemiology of MR-CoNS in Africa.
View Article and Find Full Text PDFAm J Trop Med Hyg
September 2025
Mayo Clinic, Rochester, Minnesota.
This cross-sectional descriptive study was conducted at the University of Health Sciences, Lahore, over 5 years (2016-2020) to explore the association of Panton-Valentine leucocidin (pvl) genes and staphylococcal cassette chromosome mec (SCCmec) types with hospital-acquired (HA) and community-acquired methicillin-resistant Staphylococcus aureus (MRSA). Panton-Valentine leucocidin genes in MRSA have been found in HA-MRSA strains, thereby raising the prevalence of highly virulent and resistant strains. Furthermore, the usage of staphylococcal cassette chromosome mec (SCCmec) typing is crucial for understanding the epidemiology and evolution of MRSA.
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