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Doppler echocardiography is the gold standard for assessment of diastolic dysfunction, which is increasingly recognised as a cause of heart failure, especially in the elderly. Using a combination of Doppler echocardiography techniques, it is possible to identify grades of diastolic dysfunction, estimate left ventricular filling pressures and establish the chronicity of diastolic dysfunction. These physiologically-derived measures have been widely validated against invasive measurements of left heart pressures and have been shown to be prognostically valuable in a wide range of clinical settings. This review explores the mechanisms, and approaches to the assessment of diastolic dysfunction in the elderly. The challenge for clinicians is to identify pathophysiological changes from those associated with normal ageing. When used in combination, and taking age into account, Doppler echocardiographic parameters are helpful in the assessment of dyspnoea in older patients and provide prognostic insights.
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http://dx.doi.org/10.11909/j.issn.1671-5411.2016.03.008 | DOI Listing |
J Obes Metab Syndr
September 2025
Integrated Perioperative Geriatric Excellent Research Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Background: Morbid obesity is a well-established risk factor for cardiovascular disease. Diastolic dysfunction, particularly in non-cardiac surgeries, has been associated with increased incidence of adverse cardiovascular events. This study aimed to evaluate the prevalence of diastolic dysfunction in morbidly obese patients undergoing bariatric surgery and to identify associated clinical risk factors using transesophageal echocardiography (TEE).
View Article and Find Full Text PDFComput Methods Programs Biomed
August 2025
CardioVascular Systems Imaging and Artificial Intelligence Lab, National Heart Centre Singapore, Singapore; Duke-NUS Medical School, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore. Electronic address:
Background And Objective: To develop an end-to-end artificial intelligence solution-video-based Multi-Point Tracking Network (MPTN), for detecting and tracking atrioventricular junction (AVJ) points from cardiovascular magnetic resonance and deriving AVJ motion parameters.
Methods: The MPTN model consists of two modules: AVJ point detection and AVJ motion tracking. The detection module utilizes convolutional-based feature extraction and elastic regression to detect all candidate AVJ points.
Int J Cardiol
September 2025
Federico II University, Naples, Italy; Federico II University Hospital, Naples, Italy. Electronic address:
Background: Peripartum cardiomyopathy (PPCM) is a rare, life-threatening form of heart failure occurring in late pregnancy or postpartum, with variable clinical course and outcomes. We report preliminary clinical and echocardiographic findings from a national Italian registry of PPCM patients METHODS: The study was approved by the institutional Ethics Committee and registered at ClinicalTrials.gov (NCT05878041).
View Article and Find Full Text PDFEur J Neurol
September 2025
Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy.
Background: Migraine is associated with an increased cardiovascular risk, including hypertension. Anti-calcitonin gene related peptide (CGRP) monoclonal antibodies (mAbs) are effective preventive treatments, but concerns have been raised about their potential hypertensive effects. Herein, we assess the early changes in blood pressure (BP) during anti-CGRP mAbs treatment in patients with migraine using 24-h Holter monitoring.
View Article and Find Full Text PDFAcad Radiol
September 2025
Ganzhou Institute of Medical Imaging, Ganzhou Key Laboratory of Medical Imaging and Artificial Intelligence, Medical Imaging Center, Ganzhou People's Hospital, The Affiliated Ganzhou Hospital of Nanchang University, 16th Meiguan Avenue, Ganzhou 341000, PR China (W.L., B.F., Y.K., J.Z.). Electronic a
Rationale And Objectives: This study aimed to investigate the role of cardiac magnetic resonance (CMR)-derived left atrial (LA) strain parameters in evaluating early cardiac dysfunction in hypertensive patients and to assess their diagnostic utility for left ventricular diastolic dysfunction (LVDD).
Methods: A total of 150 hypertensive patients and 60 healthy controls were retrospectively enrolled, with all participants undergoing both echocardiographic and CMR examinations. Hypertensive patients were stratified by LVDD severity based on current guidelines.