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http://dx.doi.org/10.1016/j.nefro.2016.02.004 | DOI Listing |
Immunol Res
September 2025
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Belisario Domínguez Sección XVI, Avenida Vasco de Quiroga 15, C.P. 14080, Tlalpan, Mexico City, Mexico.
We present six patients with dysautonomia secondary to primary Sjögren's disease (pSjD) and analyze the literature regarding this topic. Case series. Patients were retrospectively recruited from a tertiary center in Mexico from 2001 to 2022 and included if they met 2016 ACR/EULAR criteria for SjD.
View Article and Find Full Text PDFChin Med J (Engl)
September 2025
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Background: Sjögren's disease (SjD) is an autoimmune disorder characterized by sicca syndrome with undetermined roles of reactive oxygen species (ROS) and mitochondrial dynamics in the damaged glands. This study aimed to clarify the roles of ROS and mitochondrial dynamics in SjD-related hyposalivation and explored the therapeutic effect of targeting mitochondrial fission to treat hyposalivation in murine SjD.
Methods: Single-cell sequencing analysis of submandibular glands (SMGs) from mice with SjD was performed.
Acta Derm Venereol
September 2025
Evidence-based Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan; Orthopedics Department, Chi-Mei Medical Center, Tainan, Taiwan; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin,
Prurigo nodularis (PN) has been associated with autoimmune diseases, though longitudinal data are limited. This study investigates the risk of autoimmune disease development in PN patients using a global electronic health record database. This retrospective cohort study analysed data from the Global Collaborative Network within the TriNetX research network.
View Article and Find Full Text PDFExpert Rev Mol Med
September 2025
Exp Eye Res
September 2025
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.
The ocular surface microbiome plays a crucial role in maintaining immune homeostasis, and its disruption may contribute to mucosal inflammation and autoimmunity. This pilot exploratory study investigated and compared the ocular surface bacterial microbiome in patients with Stevens-Johnson syndrome (SJS), Sjögren's disease (SjD), and healthy controls using next-generation sequencing (NGS) and correlated these findings with dry eye parameters. Conjunctival swabs were collected from sixteen individuals: ten with SJS, three with SjD, and three healthy controls.
View Article and Find Full Text PDF