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Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer. | LitMetric
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Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer.

Mohammad Mahdi Hasani-Sadrabadi , Shahrouz Taranejoo , Erfan Dashtimoghadam , Ghasem Bahlakeh , Fatemeh Sadat Majedi , Jules John VanDersarl , Mohsen Janmaleki , Fatemeh Sharifi , Arnaud Bertsch , Kerry Hourigan , Lobat Tayebi , Philippe Renaud , Karl I Jacob

Adv Mater

Parker H. Petit Institute for Bioengineering and Bioscience, G. W. Woodruff School of Mechanical Engineering and School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0295, USA.

Published: June 2016

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20

Article Abstract

A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.

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 Source
http://dx.doi.org/10.1002/adma.201502697DOI Listing

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