Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: The cardiovascular liability of candidate compounds can be evaluated by a number of methods including implanted telemetry, jacketed telemetry and surface lead electrocardiogram (ECG). The utility of the new PhysioTel™ Digital M11 cardiovascular telemetry implant was evaluated in monkeys and dogs.
Methods: Eight monkeys and dogs (4 males and 4 females per species) were implanted with the M11 device utilizing a femoral blood pressure catheter and periosteal ECG leads. The signal quality of the ECGs was determined as a percentage of software-matched waveforms and as a percentage of signal loss during the recording periods. To investigate sensitivity for detecting changes in QT/QTc and HR/BP, moxifloxacin and doxazosin were administered to monkeys and dogs implanted with the M11 device. Additionally, histopathological evaluation of the implant site was completed.
Results: For both monkey and dog, the percentage of recognizable waveforms was high (65% and 85%, respectively), while the average amount of signal loss was low (1% and 3%, respectively), indicating that the M11 implants delivered data of sufficient quality. In monkeys, moxifloxacin (90mg/kg) induced QT and QTc prolongation up to 22 and 12ms, respectively, while at 30mg/kg in dogs, the maximal increases in QT and QTc were 13 and 16ms, respectively. Doxazosin (1.5 and 1.0mg/kg) produced HR increases up to 35 and 29bpm with decreases in blood pressure up to -14 and -26mmHg in monkeys and dogs, respectively. The histopathological impact of the implant, catheter and biopotential leads was limited to expected minor local inflammatory changes as assessed at necropsy and with microscopic examination.
Discussion: Based upon the results of this study, the PhysioTel™ Digital M11 is a suitable technology for assessing cardiovascular parameters in monkeys and dogs, and because of the size and limited invasiveness of the implant, is well positioned for use on toxicology studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.vascn.2016.01.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An analysis of behavioral characteristics and enrollment year variability in 47,444 dogs entering the Dog Aging Project from 2020 to 2023.
PLoS One
September 2025
Department of Population Health Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America.
Understanding dog behavior, especially in the context of the human social environment, is critical to maintaining positive human-dog interactions and relationships. Furthermore, behavior can be an important indicator of health and welfare in companion dogs. Behavioral change can signal transitions in life stages, alert caretakers to potential illnesses or injuries, and is an important factor in understanding and measuring stress.
View Article and Find Full Text PDFTime to face mask/spacer acceptance in dogs and cats.
Can Vet J
September 2025
Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Road, North Grafton, Massachusetts 01536, USA.
Objective: Aerosol medications are recommended for use in dogs and cats. Perceived pet intolerance to a face mask/spacer might prevent clinicians from recommending them, and thus prevent owners from using them. Our goal was to evaluate the duration required to train a pet to accept a face mask/spacer.
View Article and Find Full Text PDFCat, dog, and horse allergies: emerging new insights.
Turk J Pediatr
September 2025
Division of Allergy and Asthma, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Animal allergens, particularly those from cats, dogs, and horses, are significant risk factors for the development of allergic diseases in childhood. Managing animal allergies requires allergen avoidance and, when this is not feasible, specific immunotherapy. Patient history remains the cornerstone of diagnosis, providing the foundation for diagnostic algorithms.
View Article and Find Full Text PDFUrinary oxytocin levels in children meeting a Hospital Dog.
BMC Complement Med Ther
September 2025
Department of Women´s and Children´s Health, Uppsala University, Uppsala, S-751 85, Sweden.
Unlabelled: There has been growing interest in animal-assisted therapy (AAT) in recent decades due to increasing reports indicating its health benefits for adult patients. These benefits are partly attributed to changes, usually increased levels of the neuropeptide oxytocin. AIM: To investigate changes in oxytocin levels in hospitalized children meeting a certified Hospital Dog.
View Article and Find Full Text PDFPancreatic Islet Transplantation in Extrahepatic Sites: Evaluation of the Venous Sac in Large Mammal Models.
Diabetes Metab J
September 2025
Institute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Background: The long-term clinical efficacy of intraportal islet transplantation is hampered by islet loss due to inflammation, oxidative stress, and insufficient vascularization. This study explores the venous sac as an alternative implantation site for islet transplantation in large animal models.
Methods: An immunosuppressed, diabetic cynomolgus monkey received allogeneic islet implants in its mesenteric venous sac, with metabolic assessments over 112 days.