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Article Abstract
Whether and how DNA methylation influences the binding of transcription factors (TFs) to their corresponding DNA sequence motifs remains largely unresolved. In a recent publication, Schübeler and co‐workers (Domcke , 2015) identify a few methylation‐restricted TFs in mouse embryonic stem cells, including NRF1. The authors show that NRF1 binding to its motif can be outcompeted by DNA methylation, suggesting that methylation‐sensitive TFs rely on neighbouring motifs —bound by pioneer TFs—to ensure local hypomethylation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755117 | PMC |
| http://dx.doi.org/10.15252/embj.201593750 | DOI Listing |
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