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The early detection of melanoma is one of the greatest challenges in clinical practice of dermatology, and the reticular pattern is one of the most important dermoscopic structures to improve melanocytic lesion diagnosis. A texture-based approach is developed for the automatic detection of reticular patterns, whose output will assist clinical decision-making. Feature selection was based on the use of two algorithms by means of the classical graylevel co-occurrence matrix and Laws energy masks optimized on a set of 104 dermoscopy images. The AdaBoost (adaptive boosting) approach to machine learning was used within this strategy. Results suggest superiority of LEM for reticular pattern detection in dermoscopic images, achieving a sensitivity of 90.16% and a specificity of 86.67%. The use of automatic classification in dermoscopy to support clinicians is a strong tool to assist diagnosis; however, the use of automatic classification as a complementary tool in clinical routine requires algorithms with high levels of sensitivity and specificity. The results presented in this work will contribute to achieving this goal.
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http://dx.doi.org/10.1117/1.JMI.2.4.044503 | DOI Listing |
PLoS One
September 2025
Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan.
In adult mammals and other highly developed animals, incomplete wound healing, scar formation, and fibrosis occur. No treatment for complete tissue regeneration is currently available. However, in mice, at up to 13 days of gestation, early embryonic wounds regenerate without visible scarring.
View Article and Find Full Text PDFLangmuir
September 2025
Department of Mechanical and Industrial Engineering, Montana State University, Bozeman, Montana 59717, United States.
Global challenges posed by freshwater scarcity and the water-energy nexus drive demand for novel macromolecular design of tailored nanostructures endowed with a variety of hydrophilic and hydrophobic features. Offering potential to meet this demand, metal-organic framework (MOF) materials are synthesized from coordinated formations that create versatile reticular structures with variable water adsorption affinities. However, advances in the fundamental understanding of water interactions within these structures are impeded by the failure of classical analyses to identify mechanisms of interaction, connect fundamental isotherm types, and provide appropriate benchmarks for assessment.
View Article and Find Full Text PDFBiomaterials
August 2025
Fischell Department of Bioengineering, University of Maryland, College Park, USA; Biophysics Program, University of Maryland, College Park, USA. Electronic address:
Lymph nodes are highly specialized immune organs that orchestrate the adaptive immune response. In the lymph nodes, naïve B and T lymphocytes encounter cognate antigens, sparking their activation and response to foreign substances. Lymph nodes grow in response to an immune challenge, at least in part to accommodate increased numbers of infiltrating and proliferating B and T lymphocytes.
View Article and Find Full Text PDFBrain Res
September 2025
Neuroscience Laboratory for Cognitive and Developmental Disorders, Department of Anatomy, Medical College of Jinan University, Guangzhou 510632, China. Electronic address:
Orexin (Orx) is a vital peptide neurotransmitter essential for regulating feeding, sleep-wake cycles, and reward-seeking behavior. Orexinergic neurons are predominantly located in the lateral hypothalamus (LH). However, the precise neural connectivity of these neurons across the brain remains insufficiently characterized.
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Physiology and Pharmacology, State University of New York - Downstate Health Sciences University, Brooklyn, NY 11203, USA.
Despite recent advancements in mapping thalamic and cortical projections, the specific organization of intrathalamic and corticothalamic connectivity remains elusive. Current experimental approaches cannot definitively determine whether these connections are arranged in reciprocal (closed-) or non-reciprocal (open-loop) circuits. We developed a biophysically detailed multi-compartmental model of the mouse whisker pathway, built on anatomical and physiological data.
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