Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
To determine the optimum process conditions for dry granulating technique of Qibai Pingfei granule, granule excipient type, rolling wheel speed and pressure and feeding speed were studied. Taking shaping rate at a time, moisture absorption and dissolubility as index, the type and amount of granule excipient were determined. In addition, taking shaping rate at a time as index, parameters of rolling wheel speed and pressure and feeding speed were researched through single factor test and response surface methodology. The optimum parameters were as follows: lactose as excipient, dry extract powder to excipient at 1:2, rolling wheel speed and pressure at 10.9 Hz and 6.4 MPa and feeding speed at 7.2 Hz. After validation of three batches pilot-scale production, the optimum processing parameters for dry granulating technique of Qibai Pingfei granule is reasonable and feasible, which can provide reliable basis for production.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Physicochemical, microbiological, and microstructural changes in germinated wheat grain.
PLoS One
September 2025
Department of Science, LLP "Research and Production Enterprise "Innovator", Astana, Kazakhstan.
This study investigates the physicochemical, microbiological, and microstructural changes in soft wheat grain during germination under varying moisture conditions: moderately dry, moist, and wet. Pre-harvest sprouting can severely compromise grain quality and usability; however, understanding germination-induced changes offers insights into potential utilization strategies. Physical parameters-including thousand-kernel weight, test weight, and falling number-showed strong correlation with germination time, decreasing by 8.
View Article and Find Full Text PDFEffects of Roller Compaction on Dissolution of Granules and Tablets Captured in the Development of Two Real Pharmaceutical Formulations.
AAPS PharmSciTech
September 2025
Department of Organic Technology, Faculty of Chemical Technology, University of Chemistry and Technology, Technická 5, 166 28, Prague, Czech Republic.
Roller compaction is often utilized as the first step to improve flow properties and homogeneity of pharmaceutical mixtures. Since the dry granulation process is less complicated than its counterparts in the industry, it is possible to perform screening experiments readily to investigate granulate quality for further operations. In this study, the aim of the investigation focused on the effect of roller compaction on the dissolution of granules and tablets of two pharmaceutical formulations that contain APIs of different biopharmaceutical classification.
View Article and Find Full Text PDFNickel removal performance and process characterization of indigenous Desmodesmus strains isolated from contaminated environments.
J Environ Manage
August 2025
Departamento de Eficiencia Energética y Biotecnología Ambiental, Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA), Av. E. Bustillo 9500, CP 8400, S.C. de Bariloche, Río Negro, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. El
Metal contamination is a growing concern due to its toxicity, persistence, and accumulation in ecosystems. This problem requires efficient remediation strategies. Unicellular algae are effective at removing metals from solution.
View Article and Find Full Text PDFEnhancing Chemical Stability and Bioavailability of Aneratrigine Capsules via Dry Granulation: Addressing Stability Challenges in Sodium Bicarbonate-Containing Formulations for Clinical Development.
Pharmaceutics
August 2025
Medicinal Chemistry and New Drug Formulation Center, iN Therapeutics Co., Ltd., Yongin-si 17028, Republic of Korea.
: Aneratrigine, a potent selective Nav1.7 inhibitor, faced challenges in developing a clinically viable oral formulation due to its poor aqueous solubility in acidic gastric conditions (0.06 mg/mL at pH 1.
View Article and Find Full Text PDFSequential extraction of cyanophycin granule polypeptide and lipids from algal-bacterial consortia: Simultaneous recovery of biopolymer and fat acids.
Int J Biol Macromol
August 2025
Department of Environment, College of Environment and Resources, Xiangtan University, Xiangtan 411105, China; Chenjiang Laboratory, Chenzhou, Hunan 423000, PR China. Electronic address:
The algal-bacterial consortia have garnered significant attention for its efficacy in pollutant removal and the recovery of value-added chemicals. However, the extraction of diverse chemicals (e.g.
View Article and Find Full Text PDF