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Purpose: We have previously demonstrated that a shock index, pediatric age adjusted (SIPA) accurately identifies severely blunt injured children. We aimed to determine if SIPA could more accurately identify children with severe traumatic brain injury (TBI) than hypotension alone.
Methods: We performed subset analysis of those children with TBI among a cohort of children age 4-16 years with blunt trauma and injury severity score ≥15 from 1/07 to 6/13. We evaluated the ability of four markers to identify the most severely brain injured children. Markers included hypotension, elevated SIPA, abnormal GCS motor score (GMS), and elevated SIPA or abnormal GMS. We aimed to determine which of these four markers had the highest sensitivity in identifying severely injured children.
Results: Three hundred and ninety-two (392) children were included. Hypotension was present in 24 patients (6%); elevated SIPA in 106 (27 %), abnormal GMS in 172 (44%), and elevated SIPA or abnormal GMS in 206 (53%). All markers were able to accurately identify severely injured children with TBI. Elevated SIPA or abnormal GMS identified a greater percentage of patients with each of seven complications with higher sensitivity than each of the three other markers.
Conclusion: Among blunt injured children with TBI, elevated SIPA or abnormal GMS identifies severely brain injured children.
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http://dx.doi.org/10.1007/s00383-015-3789-6 | DOI Listing |
Injury
September 2025
Peyton Manning Children's Hospital at Ascension St. Vincent, 2001W. 86th Street, Indianapolis, IN 46260, USA. Electronic address:
Background: Shock index (SI) has been used to identify patients at risk for severe injury and predict those who require an emergent intervention. In adults, SI > 0.9 is considered elevated.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
July 2025
From the Division of Pediatric Surgery (A.B.-C., E.K.M., S.N.A.), Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado; and Department of Surgery (D.D.B.), Denver Health and Hospital Authority, Denver, Colorado.
The objective of this scoping review is to evaluate the utility and limitations of elevated shock index, pediatric age adjusted (SIPA), and provide guidance regarding how and when to use SIPA and highlight gaps in current research. Since its inception, SIPA has become a standard metric used in pediatric trauma triage. We included 38 studies that evaluated SIPA as an outcome in various pediatric trauma populations.
View Article and Find Full Text PDFBiophys J
January 2025
Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania; Department of Surgery, Penn State College of Medicine, Hershey, Pennsylvania. Electronic address:
Supraphysiological shear rates (>2000 s) amplify von Willebrand factor unfurling and increase platelet activation and adhesion. These elevated shear rates and shear rate gradients also play a role in shear-induced platelet aggregation (SIPA). The primary objective of this study is to investigate the contributions of major binding receptors to platelet deposition and SIPA in a stenotic model.
View Article and Find Full Text PDFPediatr Surg Int
November 2024
Division of Pediatric Surgery, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 E 16th Ave. Box 323, Aurora, CO, 80045, USA.
Injury
January 2025
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: An abnormal shock index (SI) is associated with greater injury severity among children with trauma. We sought to empirically-derive age-adjusted SI cutpoints associated with major trauma in children, and to compare the accuracy of these cutpoints to existing criteria for pediatric SI.
Methods: We performed a retrospective cohort study using the 2021 National Trauma Data Bank (NTDB) Participant Use File.