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We encountered a case of localized IgG4-cholecystitis mimicking gallbladder cancer with focal/segmental type1 autoimmune pancreatitis (AIP). In this case, we were unable to exclude a diagnosis of gallbladder cancer and thus performed radical cholecystectomy. Type1 AIP is often associated with gallbladder lesions, accompanied by generally diffuse, circumferential thickening of the gallbladder wall. Although localized IgG4-related cholecystitis is extremely rare, differentiating this condition from gallbladder cancer is often very difficult.
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http://dx.doi.org/10.2169/internalmedicine.54.4383 | DOI Listing |
Eur J Case Rep Intern Med
August 2025
Department of Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, USA.
Unlabelled: Autoimmune haemolytic anaemia (AIHA) is caused by antibody-mediated destruction of red blood cells. There are two broad categories of AIHA: warm and cold, both categorized by the thermal reactivity of the autoantibodies. Cold agglutinin disease (CAD) occurs at temperatures below normal body temperature and primarily involves IgM antibodies.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Importance: Patients with advanced cancer frequently receive broad-spectrum antibiotics, but changing use patterns across the end-of-life trajectory remain poorly understood.
Objective: To describe the patterns of broad-spectrum antibiotic use across defined end-of-life intervals in patients with advanced cancer.
Design, Setting, And Participants: This nationwide, population-based, retrospective cohort study used data from the South Korean National Health Insurance Service database to examine broad-spectrum antibiotic use among patients with advanced cancer who died between July 1, 2002, and December 31, 2021.
J Gastrointest Cancer
September 2025
Department of Surgery, Division of Transplant & Hepatobiliary Surgery, Organ Transplant Center, University of Iowa Health Care Medical Center, 200 Hawkins Dr, Iowa City, IA, USA.
Purpose: Gallbladder squamous cell carcinoma (SCC) is a rare subtype of gallbladder malignancy, comprising only 1-4% of cases. Ectopic expression of β-human chorionic gonadotropin (β-hCG) has been described in various epithelial cancers and is associated with aggressive behavior. We report the first known case of gallbladder SCC with diffuse β-hCG expression and markedly elevated serum β-hCG levels, aiming to explore its clinicopathological implications and potential as a prognostic biomarker.
View Article and Find Full Text PDFFront Surg
August 2025
Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Background: In recent years, global cholecyst-related disorders have been increasing daily. Laparoscopic cholecystectomy (LC) is an advanced gallbladder surgical technique. However, pneumoperitoneum and various factors leading to abdominal distension and other gastrointestinal dysfunctions are common postoperative complications.
View Article and Find Full Text PDFEur J Surg Oncol
July 2025
General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, PISA, Italy.
Introduction: Surgery for resectable gallbladder cancer (GbC) encompasses complex operative management, and evaluating surgical quality through textbook outcome (TO) is crucial. This study aimed to assess TO incidence and impact in a global cohort, identify independent predictors, and evaluate TO rates of minimally invasive (MI) techniques, including robotic (ROB) and laparoscopic (LPS).
Materials And Methods: This cohort study included patients undergoing curative-intent hepatectomy and lymphadenectomy for GbC (T1b-T3) from 2012 to 2023 in 41 hospitals.