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In this paper, we propose and demonstrate the synthetic aperture imaging by using spatial modulation diversity technology with stochastic parallel gradient descent (SPGD) algorithm. Instead of creating diversity images by means of focus adjustments, the technology, proposed in this paper, creates diversity images by modulating the transmittance of individual sub-aperture of multi-aperture system, respectively. Specifically, spatial modulation is realized by switching off the transmittance of each sub-aperture with electrical shutters, alternately. Based on these multi diversity images, SPGD algorithm is used for adaptively optimizing the coefficients of Zernike polynomials to reconstruct the real phase distortions of multi-aperture system and to restore the near-diffraction-limited image of object. Numerical simulation and experimental results show that this technology can be used for joint estimation of both pupil aberrations and an high resolution image of the object, successfully. The technology proposed in this paper can have wide applications in segmented and multi-aperture imaging systems.
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http://dx.doi.org/10.1364/OE.23.014836 | DOI Listing |
BMC Ecol Evol
September 2025
Lehrstuhl für Zoologie, TUM School of Life Sciences, Technical University of Munich, Liesel-Beckmann Strasse 4, Freising, 85354, Germany.
Accurate three-dimensional localisation of ultrasonic bat calls is essential for advancing behavioural and ecological research. I present a comprehensive, open-source simulation framework-Array WAH-for designing, evaluating, and optimising microphone arrays tailored to bioacoustic tracking. The tool incorporates biologically realistic signal generation, frequency-dependent propagation, and advanced Time Difference of Arrival (TDoA) localisation algorithms, enabling precise quantification of both positional and angular accuracy.
View Article and Find Full Text PDFHandb Exp Pharmacol
September 2025
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
GPCRs are known for their versatile signaling roles at the plasma membrane; however, recent studies have revealed that these receptors also function within various intracellular compartments, such as endosomes, the Golgi apparatus, and the endoplasmic reticulum. This spatially distinct signaling, termed location bias, allows GPCRs to initiate unique signaling cascades and influence cellular processes-including cAMP production, calcium mobilization, and protein phosphorylation-in a compartment-specific manner. By mapping the impact of GPCR signaling from these subcellular locations, this chapter emphasizes the mechanisms underlying signaling from intracellular receptor pools in diversifying receptor functionality.
View Article and Find Full Text PDFNat Commun
September 2025
Institute of Neurosciences and Medicine, Brain & Behaviour (INM-7), Research Centre Juelich; Wilhelm-Johnen-Straße 1, Juelich, Germany.
Autism is a neurodevelopmental condition associated with altered resting-state brain function. An increased excitation-inhibition ratio is discussed as a pathomechanism but in-vivo evidence of disturbed neurotransmission underlying functional alterations remains scarce. We compare local resting-state brain activity and neurotransmitter co-localizations between autism (N = 405, N = 395) and neurotypical controls (N = 473, N = 474) in two independent cohorts and correlate them with excitation-inhibition changes induced by glutamatergic (ketamine) and GABAergic (midazolam) medication.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China.
Decades of antibiotic misuse have spurred an antimicrobial resistance crisis, creating an urgent demand for alternative treatment options. Although phototherapy has therapeutic potential, the efficacy of the most advanced photosensitizers (PS) is essentially limited by aggregation-induced quenching, which significantly reduces their therapeutic effect. To address these challenges, we developed a cationic metallocovalent organic framework (CRuP-COF) via a solvent-mediated dual-reaction synthesis strategy.
View Article and Find Full Text PDFPharmacol Biochem Behav
September 2025
Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Universidad de Málaga (UMA), Málaga, 29010, Spain; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, Spain. Electronic address:
Adolescence is a period of heightened neuroplasticity and vulnerability to environmental insults, including drug exposure. In this study, we investigated the short- and long-term behavioral effects, as well as the long-term hippocampal effects, of chronic cocaine administration during adolescence, along with the potential neuroprotective role of insulin-like growth factor 2 (IGF2) in male C57BL/6J mice. Over 21 days, mice received daily intraperitoneal injections of saline, cocaine, IGF2, or a combination of cocaine and IGF2.
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