Hippocampal sharp-wave ripples in waking and sleeping states.

Curr Opin Neurobiol

Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, United States. Electronic address:

Published: December 2015


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Article Abstract

Waking and sleeping states are privileged periods for distinct mnemonic processes. In waking behavior, rapid retrieval of previous experience aids memory-guided decision making. In sleep, a gradual series of reactivated associations supports consolidation of episodes into memory networks. Synchronized bursts of hippocampal place cells during events called sharp-wave ripples communicate associated neural patterns across distributed circuits in both waking and sleeping states. Differences between sleep and awake sharp-wave ripples, and in particular the accuracy of recapitulated experience, highlight their state-dependent roles in memory processes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641767PMC
http://dx.doi.org/10.1016/j.conb.2015.05.001DOI Listing

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