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Mediators Inflamm
September 2025
Shengli Clinical Medical College of Fujian Medical University, Fuzhou 350001, Fujian, China.
Osteoporosis is a prevalent metabolic bone disorder with complex molecular underpinnings. Emerging evidence implicates endoplasmic reticulum stress (ERS) in its pathogenesis; however, systematic exploration of ERS-related genes (ERSRGs) remains limited. This study aimed to identify ERS-related differentially expressed genes (ERSRDEGs) in osteoporosis, construct a diagnostic model, and elucidate associated molecular mechanisms.
View Article and Find Full Text PDFFront Neurol
August 2025
Unit of Child Neurology and Psychiatry, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Introduction: Restless Legs Syndrome (RLS), known as Willis-Ekbom disease, is a common neurological condition that often goes undiagnosed, especially in children. Characterized by an irresistible urge to move the legs, it is typically more pronounced in the evening and at rest. Growing Pains (GP), common in childhood and associated with migraine, present apparently overlapping symptoms with RLS, making it sometimes difficult to distinguish between the two.
View Article and Find Full Text PDFMater Today Bio
October 2025
Radboud University Medical Center, Research Institute for Medical Innovation, Department of Medical BioSciences, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.
Severe scarring is an inevitable consequence of large full-thickness skin wounds, often leading to long-term complications that affect patients' well-being and necessitate extended medical interventions. While autologous split-thickness skin grafts remain the clinical standard for wound treatment, they frequently result in contractures, excessive scarring, and the need for additional corrective procedures. To address these challenges, bioengineered skin substitutes capable of promoting efficient healing while reducing complications are highly desirable.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
Department of Chemistry and Sustainable Technology, University of Eastern Finland, Joensuu Campus, Yliopistokatu 7, FI-80100, Joensuu, Finland.
Accurate thermodynamic calculations for aluminum alkyls require proper treatment of low-frequency vibrations poorly described by the harmonic approximation (HA). Here, we present a systematic investigation of hindered rotation and out-of-plane bending in aluminum trichloride (ATC) and its methyl derivatives, employing advanced computational methods to perform anharmonic entropy corrections, such as torsional eigenvalue summation (TES), the extended two-dimensional torsion method (E2DT), the multi-structural approximation with torsional anharmonicity (MS-T), and Fourier grid Hamiltonian (FGH). Our results reveal distinct structure-dependent behaviors: monomers exhibit near-free methyl rotations where the HA overestimates entropy by 20-30 J K mol, while dimers show more hindered rotations adequately described by the HA around room temperature.
View Article and Find Full Text PDFArch Gerontol Geriatr
August 2025
School of Nursing, Faculty of Health and Social Science, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China; Research Institute for Smart Ageing (RISA), The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China; WHO Collaborating Centre for Community Health Services, Sch
Background: Older adults with cognitive impairment face significant challenges in maintaining oral health while the barriers and facilitators for implementing communitybased oral health interventions are uncertain.
Objective: To understand the barriers and facilitators for the implementation of oral health intervention among community-dwelling older adults with cognitive impairment.
Methods: Literature was searched in PubMed, CINAHL, Embase, PsycINFO, Scopus and Google Scholar.