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Spinal radiculopathy (SR) is a multifactorial nerve root injury that can result in significant pain, psychological stress and disability. It can occur at any level of the spinal column with the highest percentage in the lumbar spine. Amongst the various interventions that have been suggested, neural mobilization (NM) has been advocated as an effective treatment option. The purpose of this review is to (1) examine pathophysiological aspects of spinal roots and peripheral nerves, (2) analyze the proposed mechanisms of NM as treatment of injured nerve tissues and (3) critically review the existing research evidence for the efficacy of NM in patients with lumbar or cervical radiculopathy.
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http://dx.doi.org/10.1016/j.jbmt.2014.08.006 | DOI Listing |
Brain Res Bull
September 2025
Department of Physiology Faculty of Medicine, Kansai Medical University, 2-5-1 Shin-machi Hirakata, Osaka 573-1010, Japan. Electronic address:
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that mediate slow glutamatergic signal transduction and regulate cell excitability in the central nervous system. Group I mGluRs are coupled to G proteins and mobilize intracellular Ca. Group II mGluRs are coupled to G proteins and inhibit adenylyl cyclase.
View Article and Find Full Text PDFTrends Neurosci Educ
September 2025
Laboratory for Research in Neuroeducation (LRN), Université du Québec à Montréal, Montreal, Quebec, Canada; Team for Research in Science and Technology Education (EREST), Université du Québec à Montréal, Montreal, Quebec, Canada; Départment de didactique, Université du Québec à Montréal
Background: Frequent and persistent errors resist teaching, partly due to difficulties in mobilizing inhibitory control. A promising strategy to address this challenge involves teaching students about neuroplasticity. Such instruction may indeed foster motivational beliefs (often referred to as growth mindset), which in turn could positively influence the mobilization of inhibitory control.
View Article and Find Full Text PDFMol Psychiatry
August 2025
University of Chinese Academy of Sciences, Beijing, China.
Neuroimmune signals can regulate neuronal function and affect behavior through mechanisms that are not yet fully understood. Here we investigated the action of interleukin 13 (IL-13), a cytokine that can be produced in the brain by both microglia and neurons. We show that dopamine-containing neurons in the ventral tegmental area (VTA) predominantly express the IL-13 receptor alpha 1 (IL-13Rα1) and exhibit presynaptic vesicular localization of neuronal IL-13.
View Article and Find Full Text PDFCogn Affect Behav Neurosci
July 2025
Department of Psychology, Nanjing University, Room 418, Heren Hall, 163 Xianlin Avenue, Nanjing, 210023, People's Republic of China.
Recent studies have found cognitive control deficits in high test anxiety (HTA) individuals, yet the underlying mechanisms remain incompletely understood. Guided by the Expected Value of Control (EVC) model, this study used a mixed factorial design to examine how task efficacy influences cognitive control in individuals with HTA. We utilized event-related potentials (ERPs) in a cued Flanker task, manipulating the evaluative threat context and task difficulty.
View Article and Find Full Text PDFJ Cell Mol Med
July 2025
Interdepartmental Centre for Stem Cells and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Extramedullary haematopoiesis (EMH) refers to blood generation outside of the bone marrow (BM). In Myelofibrosis (MF), a myeloproliferative neoplasm, the disruption of BM microenvironment promotes haematopoietic stem and progenitor cells (HSPCs) mobilisation, resulting in the onset of EMH in the spleen, and then in splenomegaly. Although JAK2 inhibitors have a good efficacy in reducing splenomegaly, the presence of a significant proportion of non-responder patients underlines the need to explore the cellular mechanisms responsible for the EMH onset.
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