Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

A new water-soluble redox-active pillar[5]arene was synthesized by incorporation of one benzoquinone unit. The pillar[5]arene showed redox-responsive reversible lower critical solution temperature changes in aqueous solution.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c5cc01630dDOI Listing

Publication Analysis

Top Keywords

reversible contrasting
4
contrasting changes
4
changes cloud
4
cloud point
4
point temperature
4
temperature pillar[5]arenes
4
pillar[5]arenes quinone
4
quinone unit
4
unit triethylene
4
triethylene oxide
4

Similar Publications

Interaction studies by NMR on the multivalent interaction between chondroitin sulfate E derivatives and the langerin receptor.

Org Biomol Chem

September 2025

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, 41092 Sevilla, Spain.

In this paper, we present the NMR analysis of multivalent compounds displaying chondroitin sulfate E (CS-E) disaccharide ligands and their interaction with langerin. The disaccharides correspond to the two alternative sequences of CS-E: GlcA-GalNAc and GalNAc-GlcA. Firstly, we studied the conformation of the two corresponding series of glycodendrimers free in solution and in the presence of langerin.

View Article and Find Full Text PDF

Phenotype-driven approaches identify disease-counteracting compounds by analysing the phenotypic signatures that distinguish diseased from healthy states. Here we introduce PDGrapher, a causally inspired graph neural network model that predicts combinatorial perturbagens (sets of therapeutic targets) capable of reversing disease phenotypes. Unlike methods that learn how perturbations alter phenotypes, PDGrapher solves the inverse problem and predicts the perturbagens needed to achieve a desired response by embedding disease cell states into networks, learning a latent representation of these states, and identifying optimal combinatorial perturbations.

View Article and Find Full Text PDF

Sentence-level semantics plays a key role in language understanding. There exist subtle relations and dependencies among sentence-level samples, which is to be exploited. For example, in relational triple extraction, existing models overemphasize extraction modules, ignoring the sentence-level semantics and relation information, which causes (1) the semantics fed to extraction modules is relation-unaware; (2) each sample is trained individually without considering inter-sample dependency.

View Article and Find Full Text PDF

Lysyl oxidase exacerbates rheumatoid arthritis through promoting angiogenesis and the proliferation of fibroblast-like synoviocytes.

Acta Biochim Biophys Sin (Shanghai)

September 2025

Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by synovial hyperplasia and pannus formation, which serves as its primary pathological feature and may ultimately result in joint deformities. Lysyl oxidase (LOX) is involved in the formation and remodeling of the extracellular matrix, but its role in RA is not yet clear. This study aims to investigate the mechanism of lysyl oxidase (LOX) in synovial hyperplasia and pannus formation associated with rheumatoid arthritis (RA).

View Article and Find Full Text PDF