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A new water-soluble redox-active pillar[5]arene was synthesized by incorporation of one benzoquinone unit. The pillar[5]arene showed redox-responsive reversible lower critical solution temperature changes in aqueous solution.
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http://dx.doi.org/10.1039/c5cc01630d | DOI Listing |
Org Biomol Chem
September 2025
Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, 41092 Sevilla, Spain.
In this paper, we present the NMR analysis of multivalent compounds displaying chondroitin sulfate E (CS-E) disaccharide ligands and their interaction with langerin. The disaccharides correspond to the two alternative sequences of CS-E: GlcA-GalNAc and GalNAc-GlcA. Firstly, we studied the conformation of the two corresponding series of glycodendrimers free in solution and in the presence of langerin.
View Article and Find Full Text PDFNat Biomed Eng
September 2025
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Phenotype-driven approaches identify disease-counteracting compounds by analysing the phenotypic signatures that distinguish diseased from healthy states. Here we introduce PDGrapher, a causally inspired graph neural network model that predicts combinatorial perturbagens (sets of therapeutic targets) capable of reversing disease phenotypes. Unlike methods that learn how perturbations alter phenotypes, PDGrapher solves the inverse problem and predicts the perturbagens needed to achieve a desired response by embedding disease cell states into networks, learning a latent representation of these states, and identifying optimal combinatorial perturbations.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
September 2025
Sentence-level semantics plays a key role in language understanding. There exist subtle relations and dependencies among sentence-level samples, which is to be exploited. For example, in relational triple extraction, existing models overemphasize extraction modules, ignoring the sentence-level semantics and relation information, which causes (1) the semantics fed to extraction modules is relation-unaware; (2) each sample is trained individually without considering inter-sample dependency.
View Article and Find Full Text PDFBrain Behav
September 2025
Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University(Tongde Hospital of Zhejiang Province), Hangzhou, China.
Background: Mental disorders frequently co-occur with pain, yet pain mechanisms in non-peripheral etiologies (e.g., chronic psychological stress) remain underexplored.
View Article and Find Full Text PDFActa Biochim Biophys Sin (Shanghai)
September 2025
Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by synovial hyperplasia and pannus formation, which serves as its primary pathological feature and may ultimately result in joint deformities. Lysyl oxidase (LOX) is involved in the formation and remodeling of the extracellular matrix, but its role in RA is not yet clear. This study aims to investigate the mechanism of lysyl oxidase (LOX) in synovial hyperplasia and pannus formation associated with rheumatoid arthritis (RA).
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