98%
921
2 minutes
20
Introduction: Conventional surgical debridement of burn wounds consists of tangential excision of eschar using a knife or dermabrasion until viable dermis or punctate bleeding occurs. The Versajet™ (Smith and Nephew, St. Petersburg, FL, USA) hydrosurgery system has also been advocated for burn wound debridement, with the suggestion that enhanced preservation of dermal tissue might reduce subsequent scarring.
Methods: A prospective randomised controlled trial was undertaken comparing Versajet™ to conventional debridement. After excluding those with facial burns, 61 children ≤16 years of age undergoing debridement and skin grafting for partial thickness burns were recruited. Adequacy of debridement was assessed by 2mm punch biopsies taken pre- and post-debridement. Surgical time, percentage graft take at day 10, time to healing, post-operative infection and scarring at 3 and 6 months were assessed.
Results: Thirty-one children underwent conventional debridement and 30 debridement using Versajet™. There was a significant difference in the amount of viable dermal preservation between the two groups (p=0.02), with more viable tissue lost in the conventional group (median 325 μm) versus the Versajet™ group (median 35 μm). There was no significant difference between graft take at day 10 (p=0.9), post-operative wound infection (p=0.5), duration of surgery (p=0.6) or time to healing after grafting (p=0.6). Despite better dermal preservation in the Versajet™ group, there was no significant difference between scarring at 3 or 6 months (p=1.0, 0.1).
Conclusions: These findings suggest that Versajet™ hydrosurgery appears a more precise method of burn wound debridement. Although dermal preservation may be a factor in reducing subsequent hypertrophic scarring, there were no significant differences found between scarring at 3 or 6 months after-injury.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.burns.2015.02.001 | DOI Listing |
Anal Chem
September 2025
Marshall Laboratory of Biomedical Engineering, Shenzhen Key Laboratory for Nano-Biosensing Technology, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518060, China.
Chronic periodontitis, a frequent complication of diabetes, is exacerbated by bacterial biofilms that drive progressive periodontal tissue destruction and systemic inflammation. Conventional treatments, utilizing mechanical debridement and systemic antibiotics, often fail to eradicate bacterial biofilms, promote antibiotic resistance, and lack real-time monitoring, leading to suboptimal therapeutic outcomes. Herein, we report a separable bilayer microneedle (MN) patch that enables localized, antibiotic-free, biofilm-targeted therapy and in situ biomarker-based monitoring for the integrated management of chronic periodontitis.
View Article and Find Full Text PDFZhejiang Da Xue Xue Bao Yi Xue Ban
September 2025
Wound Healing Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Tophaceous wounds represent a severe complication of end-stage gout, characterized by the deposition of monosodium urate (MSU) crystals leading to localized tissue ischemia, chronic inflammation, and non-healing ulcers. The pathological mechanism involves the formation of MSU crystals under persistent hyperuricemia, inflammatory encapsulation, and mechanical compression of the vascular system due to tophus enlarge-ment, ultimately resulting in chronic non-healing ulcers. This article consolidates current evidence to outline an integrated management strategy for such wounds, combining systemic metabolic control with localized interventions.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
School of Science, Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen 518055, China. Electronic address:
Dental infections continue to present significant challenges in clinical dentistry, often resulting in severe oral and systemic complications. Conventional treatments, including antibiotics and mechanical debridement, face increasing limitations due to microbial resistance and persistent biofilms. This review delves into the evolving field of biomaterials designed for dental infections, especially biological macromolecule-based biomaterials, including cellulose and chitosan, emphasizing their role in infection prevention, treatment, and tissue regeneration.
View Article and Find Full Text PDFCureus
August 2025
General Surgery, Health 1 Super Speciality Hospital, Ahmedabad, IND.
Pressure ulcers in chronically immobilized patients often become infected with multidrug-resistant organisms such as Pseudomonas aeruginosa. Management is particularly challenging in low-resource settings where advanced wound care products are unavailable. Natural, inexpensive alternatives, such as vinegar and papaya, have demonstrated antimicrobial and debriding properties, but their combined use has not been formally documented.
View Article and Find Full Text PDFBiomed Pharmacother
August 2025
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China; Department of Center for Orthopaedic Repair and Reconstruction of Chongming Hospital Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 202150, China; Institute of Wou
Diabetic foot ulcers (DFUs), as one of the most severe complications of diabetes mellitus, have emerged as a critical global public health challenge due to their high incidence, refractory nature, and serious adverse outcomes. Clinical evidence demonstrates that while conventional therapies-including wound debridement, pharmacological treatment, and surgical intervention-can partially improve wound healing, they remain limited by suboptimal efficacy and high complication rates. In recent years, breakthroughs in smart dressing technology, enabled by advanced materials and biosensing innovations, have provided transformative solutions to this clinical dilemma.
View Article and Find Full Text PDF