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Objective: To describe a novel use of fluorescent angiography in assessing donor limb perfusion prior to free tissue harvest in microvascular free tissue transfer.
Study Design: Retrospective case series.
Methods: From January 2012 to June 2013, 59 patients underwent head-and-neck microvascular free tissue reconstruction. Evaluation of donor site perfusion via indocyanine green (ICG) fluorescent angiography was utilized in 12 patients and 13 free flaps. Eleven cases were radial forearm free flaps (RFFF) and two were fibula free flaps (FFF). Preoperatively, RFFF patients were evaluated with Allen's testing, Doppler ultrasound, or both. FFF patients underwent magnetic resonance angiography. ICG was used intraoperatively to evaluate donor limb perfusion prior to free flap harvest. Intraoperative and postoperative complications of the donor limb were evaluated with cost analysis.
Results: Average follow-up was 5.3 months. Preoperative Allen's testing was normal in six patients and ultrasound was performed in eight patients. One patient had a normal ultrasound, three showed minimal dampening, and four exhibited severe waveform flattening. There were no intraoperative complications using ICG. All 12 patients displayed adequate donor limb perfusion via fluorescent angiography. No digital or acute ischemic events were identified intraoperatively or postoperatively. There was no significant decrease in functionality or mobility of the donor limb. One patient noted mild arm pain with use.
Conclusion: Fluorescent angiography is another method to evaluate donor site perfusion prior to free tissue harvest. Larger prospective analysis would be helpful to more thoroughly evaluate safety, although this is limited by the overall low risk of ischemic complications.
Level Of Evidence: 4.
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http://dx.doi.org/10.1002/lary.25190 | DOI Listing |
Eye (Lond)
September 2025
Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Objectives: To characterise the chorioretinal (CR) manifestations of West Nile virus (WNV) infection using multimodal imaging (MMI).
Methods: Retrospective cohort study including 37 patients with confirmed WNV infection hospitalised at a single centre (July-September 2024). All underwent comprehensive ophthalmological evaluations, including visual acuity, slit-lamp biomicroscopy, fundoscopy, and multimodal imaging: fundus photography, spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), fluorescein angiography, and indocyanine green angiography when clinically indicated.
Vestn Oftalmol
September 2025
OOO Prostranstvo intellektual'nykh reshenij, Novorossiysk, Russia.
Unlabelled: Automated analysis of optical coherence tomography (OCT) biomarkers improves the prediction of results of loading anti-VEGF therapy of vascular pigment epithelial detachment (PED) associated with neovascular age-related macular degeneration (nAMD).
Objective: This study evaluated the effectiveness of OCT biomarker analysis algorithm in predicting the anatomical outcomes of loading anti-VEGF therapy for vascular PED in nAMD.
Material And Methods: OCT scans performed prior to loading anti-VEGF therapy were analyzed using the algorithm in 69 treatment-naïve nAMD patients (70 eyes) with vascular PED exceeding 200 µm in height.
Transl Vis Sci Technol
September 2025
Department of Ophthalmology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
Purpose: To evaluate choroidal vasculature using a novel three-dimensional algorithm in fellow eyes of patients with unilateral chronic central serous chorioretinopathy (cCSC).
Methods: Patients with unilateral cCSC were retrospectively included. Automated choroidal segmentation was conducted using a deep-learning ResUNet model.
Invest Ophthalmol Vis Sci
September 2025
University of Health Science, Haseki Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
Purpose: The purpose of this study was to assess the reflectivity of the outer retinal layers (ORLs) in patients with central serous chorioretinopathy (CSCR) and to examine the relationship between the dimensions of the subretinal fluid (SRF) and ORL.
Methods: This retrospective, cross-sectional study included 33 eyes of 33 patients with CSCR and 33 age- and gender-matched controls. Unnormalized and relative reflectivities for the retinal pigment epithelium (RPE), the external limiting membrane (ELM), and the ellipsoid zone (EZ), as well as SRF height, base width, and area, were measured on optical coherence tomography images.
Front Pediatr
August 2025
Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
Background: The m.3243A>G mutation in the MT-TL1 gene is the most common mtDNA mutation. The mutation can lead to a spectrum of conditions, including diabetes, hearing loss, heart and muscle involvement, encephalopathy and epilepsy, gastrointestinal problems, and vision impairment, often occurring concurrently-collectively referred to as MELAS (mitochondrial encephalopathy lactic acidosis and stroke-like episodes) syndrome.
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